The sequence-structure-function paradigm has dominated twentieth century molecular
biology. The paradigm tacitly stipulated that for each sequence there exists a single, well …

Psychrophilic organisms thriving at near-zero temperatures synthesize cold-adapted
enzymes to sustain cell metabolism. These enzymes have overcome the reduced molecular …

A general limitation of the use of enzymes in biotechnological processes under sometimes
nonphysiological conditions is the complex interplay between two key quantities, enzyme …

The latitudinal diversity gradient (LDG) refers to a decrease in biodiversity from the equator
to the poles. The evolutionary speed hypothesis, backed by the metabolic theory of ecology …

Histamine is a biogenic amine found in fish-derived and fermented food products with
physiological relevance since its concentration is proportional to food spoilage and health …

Lipases and cellulases have been extensively used in the field of biotechnology for varied
purposes. Mainly, the ongoing researches focus on the improvements of kinetic and …

Introduction The deep-sea environment is always characterized by high hydrostatic
pressure, fluctuating temperatures, heavy metals, darkness, and others. The Vesicomyidae …

Glaciozyma antarctica PI12 is a psychrophilic yeast isolated from Antarctica. In this work, we
describe the heterologous production, biochemical properties and in silico structure analysis …

Why does the growth of most life forms exhibit a narrow range of optimal temperatures below
40° C? We hypothesize that the recently identified stable range of oceanic temperatures of …

Quantitatively mapping enzyme sequence-catalysis landscapes remains a critical challenge
in understanding enzyme function, evolution, and design. Here, we expand an emerging …