In this Timeline, we describe the characteristics of tumour antigens that are recognized by
spontaneous T cell responses in cancer patients and the paths that led to their identification …

Abstract Cancer/testis (CT) antigens, of which more than 40 have now been identified, are
encoded by genes that are normally expressed only in the human germ line, but are also …

Cancer/testis (CT) antigens are a category of tumor antigens with normal expression
restricted to male germ cells in the testis but not in adult somatic tissues. In some cases, CT …

Cancer/testis (CT) antigens are protein antigens with normal expression restricted to adult
testicular germ cells, and yet are aberrantly activated and expressed in a proportion of …

Cancer testis antigens (CTA) are a large family of tumor-associated antigens expressed in
human tumors of different histological origin, but not in normal tissues except for testis and …

Cancer/testis (CT) antigens are immunogenic in cancer patients, exhibit highly tissue-
restricted expression, and are considered promising target molecules for cancer vaccines …

Tumour-specific antigens have been an area of interest in cancer therapy since their
discovery in the middle of the 20th century. In the era of immune-based cancer therapeutics …

DNA methylation is not just for basic scientists any more. There is a growing awareness in
the medical field that having the correct pattern of genomic methylation is essential for …

ABSTRACT DEAD-box proteins are characterized by nine conserved motifs. According to
these criteria, several hundreds of these proteins can be identified in databases. Many …

The technological advances occurred in the last few years have led to a great increase in
the number of tumor associated antigens (TAA) that are currently available for clinical …