Ebola virus disease (EVD) is a severe and frequently lethal disease caused by Ebola virus
(EBOV). EVD outbreaks typically start from a single case of probable zoonotic transmission …

The novel betacoronavirus, SARS-CoV-2 (severe acute respiratory syndrome coronavirus
2), has spread across the globe at an unprecedented rate since its first emergence in Wuhan …

Abstract Development of effective preventative interventions against SARS-CoV-2, the
etiologic agent of COVID-19 is urgently needed. The viral surface spike (S) protein of SARS …

Background To address the unmet medical need for an effective prophylactic vaccine
against Ebola virus we assessed the safety and immunogenicity of three different two-dose …

Vaccination against infectious diseases has changed the future of the human species,
saving millions of lives every year, both children and adults, and providing major benefits to …

Background Ebola vaccine development was accelerated in response to the 2014 Ebola
virus infection outbreak. This phase 1 study (VAC52150EBL1004) assessed safety …

Since the discovery in 1796 by Edward Jenner of vaccinia virus as a way to prevent and
finally eradicate smallpox, the concept of using a virus to fight another virus has evolved into …

Replication-incompetent adenoviral vectors have been under investigation as a platform to
carry a variety of transgenes, and express them as a basis for vaccine development. A …

SARS CoV-2 and its associated disease COVID-19 has devastated the world during 2020.
Masks and social distancing could be efficient if done by large proportions of the population …

Summary Background The Ebola epidemics in west Africa and the Democratic Republic of
the Congo highlight an urgent need for safe and effective vaccines to prevent Ebola virus …