[HTML][HTML] Fine-tuning through generations: advances in structure and production of CAR-T therapy
Z Zheng, S Li, M Liu, C Chen, L Zhang, D Zhou - Cancers, 2023 - mdpi.com
Simple Summary Chimeric antigen receptor (CAR)-T cell therapy has been highly
successful in treating hematological malignancies like leukemia and lymphoma, leading to …
successful in treating hematological malignancies like leukemia and lymphoma, leading to …
[HTML][HTML] Preclinical optimization of a GPC2-targeting CAR T-cell therapy for neuroblastoma
M Sun, Y Cao, R Okada… - … for ImmunoTherapy of …, 2023 - ncbi.nlm.nih.gov
Background Although most patients with newly diagnosed high-risk neuroblastoma (NB)
achieve remission after initial therapy, more than 50% experience late relapses caused by …
achieve remission after initial therapy, more than 50% experience late relapses caused by …
[HTML][HTML] Targeting and cytotoxicity of chimeric antigen receptor T cells grafted with PD1 extramembrane domain
A Zhang, S Wang, Y Sun, Y Zhang, L Zhao… - … Hematology & Oncology, 2023 - Springer
Background Immunosuppression induced by programmed cell death protein 1 (PD1)
presents a significant constraint on the effectiveness of chimeric antigen receptor (CAR)-T …
presents a significant constraint on the effectiveness of chimeric antigen receptor (CAR)-T …
[HTML][HTML] Geometric parameters that affect the behavior of logic-gated CAR T cells
AC Partin, R Bruno, S Shafaattalab… - Frontiers in …, 2024 - frontiersin.org
Clinical applications of CAR-T cells are limited by the scarcity of tumor-specific targets and
are often afflicted with the same on-target/off-tumor toxicities that plague other cancer …
are often afflicted with the same on-target/off-tumor toxicities that plague other cancer …
[HTML][HTML] 401 Hinge length: A novel method of predicting cytotoxicity of CAR constructs against antigen-low leukemia
Background Genetic engineering of T-cells to target tumors through the expression of
synthetic chimeric antigen receptors, or CARs, has led to a breakthrough in the treatment of …
synthetic chimeric antigen receptors, or CARs, has led to a breakthrough in the treatment of …
[HTML][HTML] CAR T-Cell Therapy: A New Era in Cancer Immunotherapy
M Sahlolbei, A Ahmadieh-Yazdi, M Rostamipoor… - 2024 - intechopen.com
Chimeric antigen receptor (CAR) T-cell therapy is a revolutionary development in the field of
cancer immunotherapy, offering a targeted approach to combat various hematologic …
cancer immunotherapy, offering a targeted approach to combat various hematologic …
In vitro re-challenge of CAR T cells.
CH Klee, A Villatoro, NP Casey, EM Inderberg… - Methods in Cell …, 2023 - europepmc.org
Chimeric antigen receptor (CAR) T cells (CAR T) have emerged as a potential therapy for
cancer patients. CAR T cells are capable of recognizing membrane proteins on cancer cells …
cancer patients. CAR T cells are capable of recognizing membrane proteins on cancer cells …