[HTML][HTML] Vasopressin–aquaporin-2 pathway: recent advances in understanding water balance disorders
The alteration of water balance and related disorders has emerged as being strictly linked to
the state of activation of the vasopressin–aquaporin-2 (vasopressin–AQP2) pathway. The …
the state of activation of the vasopressin–aquaporin-2 (vasopressin–AQP2) pathway. The …
Nephronophthisis-pathobiology and molecular pathogenesis of a rare kidney genetic disease
S Gupta, JE Ozimek-Kulik, JK Phillips - Genes, 2021 - mdpi.com
The exponential rise in our understanding of the aetiology and pathophysiology of genetic
cystic kidney diseases can be attributed to the identification of cystogenic genes over the last …
cystic kidney diseases can be attributed to the identification of cystogenic genes over the last …
Astroglial modulation of hydromineral balance and cerebral edema
YF Wang, V Parpura - Frontiers in Molecular Neuroscience, 2018 - frontiersin.org
Maintenance of hydromineral balance (HB) is an essential condition for life activity at
cellular, tissue, organ and system levels. This activity has been considered as a function of …
cellular, tissue, organ and system levels. This activity has been considered as a function of …
Activation of Calcium-Sensing Receptor increases intracellular calcium and decreases cAMP and mTOR in PKD1 deficient cells
Clinical and fundamental research suggest that altered calcium and cAMP signaling might
be the most proximal events in ADPKD pathogenesis. Cells from ADPKD cysts have a …
be the most proximal events in ADPKD pathogenesis. Cells from ADPKD cysts have a …
Olive Leaf Extract (OLE) impaired vasopressin-induced aquaporin-2 trafficking through the activation of the calcium-sensing receptor
Vasopressin (AVP) increases water permeability in the renal collecting duct through the
regulation of aquaporin-2 (AQP2) trafficking. Several disorders, including hypertension and …
regulation of aquaporin-2 (AQP2) trafficking. Several disorders, including hypertension and …
Lixivaptan, a new generation diuretic, counteracts vasopressin-induced aquaporin-2 trafficking and function in renal collecting duct cells
Vasopressin V2 receptor (V2R) antagonists (vaptans) are a new generation of diuretics.
Compared with classical diuretics, vaptans promote the excretion of retained body water in …
Compared with classical diuretics, vaptans promote the excretion of retained body water in …
Activation of the calcium-sensing receptor corrects the impaired mitochondrial energy status observed in renal polycystin-1 knockdown cells modeling autosomal …
Autosomal Dominant Polycistic kidney Disease (ADPKD) is a renal channelopathy due to
loss-of-function mutations in the PKD1 or PKD2 genes, encoding polycystin-1 (PC1) or …
loss-of-function mutations in the PKD1 or PKD2 genes, encoding polycystin-1 (PC1) or …
[HTML][HTML] Urinary aquaporin 2 as a potential indicator predicting tolvaptan response in patients with ADPKD
S Makabe, S Manabe, H Kataoka, T Akihisa… - Kidney International …, 2021 - Elsevier
Introduction Tolvaptan is used to treat autosomal dominant polycystic kidney disease
(ADPKD) because it inhibits binding of the antidiuretic hormone vasopressin to the …
(ADPKD) because it inhibits binding of the antidiuretic hormone vasopressin to the …
Weight‐reducing, lipid‐lowering and antidiabetic activities of a novel arginine vasopressin analogue acting at the V1a and V1b receptors in high‐fat‐fed mice
Aim To assess the beneficial metabolic effects of the nonapeptide hormone, arginine
vasopressin (AVP), on metabolism. Materials and Methods We exchanged amino acids at …
vasopressin (AVP), on metabolism. Materials and Methods We exchanged amino acids at …
Cross-Species Insights into Autosomal Dominant Polycystic Kidney Disease: Provide an Alternative View on Research Advancement
J Luo, Y Zhang, S Jayaprakash, L Zhuang… - International Journal of …, 2024 - mdpi.com
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a prevalent hereditary disorder
that affects the kidneys, characterized by the development of an excessive number of fluid …
that affects the kidneys, characterized by the development of an excessive number of fluid …