Photoaffinity labeling (PAL) is one of the few biochemical techniques that can give direct
evidence of biomolecular interactions in cells. Several photoactivatable functional groups …

The use of computer-aided drug design (CADD) for the identification of lead compounds in
radiotracer development is steadily increasing. Traditional CADD methods, such as structure …

Purpose Previous studies from our lab utilized an ultra-high throughput screening method to
identify compound 1 as a small molecule that binds to alpha-synuclein (α-synuclein) fibrils …

Förster resonance energy transfer (FRET) is a valuable method for monitoring protein
conformation and biomolecular interactions. Intrinsically fluorescent amino acids that can be …

In the introduction chapter we introduce the volume and its three sections, namely critical
reviews, highlights on recent ''hot''topics and SPR lectures in photochemistry. Furthermore …

What is the essential requirement for the existence of living beings? In the early 19th
century, this question was approached in two different ways. The first approach proposed …

This chapter discusses the five-membered ring systems with O and N atoms such as
isoxazoles, isoxazolines, isoxazolidines, oxazoles, oxazolines, oxazolidines, and …