Neuroimaging in autism spectrum disorder: brain structure and function across the lifespan
C Ecker, SY Bookheimer, DGM Murphy - The Lancet Neurology, 2015 - thelancet.com
Over the past decade, in-vivo MRI studies have provided many invaluable insights into the
neural substrates underlying autism spectrum disorder (ASD), which is now known to be …
neural substrates underlying autism spectrum disorder (ASD), which is now known to be …
Disentangling the heterogeneity of autism spectrum disorder through genetic findings
SS Jeste, DH Geschwind - Nature Reviews Neurology, 2014 - nature.com
Autism spectrum disorder (ASD) represents a heterogeneous group of disorders, which
presents a substantial challenge to diagnosis and treatment. Over the past decade …
presents a substantial challenge to diagnosis and treatment. Over the past decade …
Interneuron dysfunction in psychiatric disorders
O Marín - Nature Reviews Neuroscience, 2012 - nature.com
Schizophrenia, autism and intellectual disabilities are best understood as spectrums of
diseases that have broad sets of causes. However, it is becoming evident that these …
diseases that have broad sets of causes. However, it is becoming evident that these …
[HTML][HTML] Current enlightenment about etiology and pharmacological treatment of autism spectrum disorder
Autistic Spectrum Disorder (ASD) is a complex neurodevelopmental brain disorder
characterized by two core behavioral symptoms, namely impairments in social …
characterized by two core behavioral symptoms, namely impairments in social …
[HTML][HTML] Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits
O Peñagarikano, BS Abrahams, EI Herman… - Cell, 2011 - cell.com
Although many genes predisposing to autism spectrum disorders (ASD) have been
identified, the biological mechanism (s) remain unclear. Mouse models based on human …
identified, the biological mechanism (s) remain unclear. Mouse models based on human …
[HTML][HTML] CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in cerebral organoids derived …
P Wang, R Mokhtari, E Pedrosa, M Kirschenbaum… - Molecular autism, 2017 - Springer
Background CHD8 (chromodomain helicase DNA-binding protein 8), which codes for a
member of the CHD family of ATP-dependent chromatin-remodeling factors, is one of the …
member of the CHD family of ATP-dependent chromatin-remodeling factors, is one of the …
Genetics of autism spectrum disorders
DH Geschwind - Trends in cognitive sciences, 2011 - cell.com
Characterized by a combination of abnormalities in language, social cognition and mental
flexibility, autism is not a single disorder but a neurodevelopmental syndrome commonly …
flexibility, autism is not a single disorder but a neurodevelopmental syndrome commonly …
Differences in white matter fiber tract development present from 6 to 24 months in infants with autism
Objective: Evidence from prospective studies of high-risk infants suggests that early
symptoms of autism usually emerge late in the first or early in the second year of life after a …
symptoms of autism usually emerge late in the first or early in the second year of life after a …
Genetic architecture in autism spectrum disorder
B Devlin, SW Scherer - Current opinion in genetics & development, 2012 - Elsevier
Autism spectrum disorder (ASD) is characterized by impairments in reciprocal social
interaction and communication, and by restricted and repetitive behaviors. Family studies …
interaction and communication, and by restricted and repetitive behaviors. Family studies …
[HTML][HTML] Rare de novo variants associated with autism implicate a large functional network of genes involved in formation and function of synapses
Identification of complex molecular networks underlying common human phenotypes is a
major challenge of modern genetics. In this study, we develop a method for network-based …
major challenge of modern genetics. In this study, we develop a method for network-based …