Dietary metabolism, the gut microbiome, and heart failure

WHW Tang, DY Li, SL Hazen - Nature Reviews Cardiology, 2019 - nature.com
Advances in our understanding of how the gut microbiota contributes to human health and
diseases have expanded our insight into how microbial composition and function affect the …

Contributory risk and management of comorbidities of hypertension, obesity, diabetes mellitus, hyperlipidemia, and metabolic syndrome in chronic heart failure: a …

B Bozkurt, D Aguilar, A Deswal, SB Dunbar… - Circulation, 2016 - Am Heart Assoc
Elevated levels of diastolic BP and especially systolic BP (SBP) are major risk factors for the
development of HF. 18, 19 One of the most impactful observations from the Framingham …

A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular …

WJ Paulus, C Tschöpe - Journal of the American College of Cardiology, 2013 - jacc.org
Over the past decade, myocardial structure, cardiomyocyte function, and intramyocardial
signaling were shown to be specifically altered in heart failure with preserved ejection …

Arterial stiffness and hypertension: chicken or egg?

GF Mitchell - Hypertension, 2014 - Am Heart Assoc
Mitchell Arterial Stiffness and Hypertension 211 in PP that is associated with high incidence
of predominantly systolic hypertension in older people. One of the foregoing studies of …

Sodium intake and heart failure

Y Patel, J Joseph - International journal of molecular sciences, 2020 - mdpi.com
Sodium is an essential mineral and nutrient used in dietary practices across the world and is
important to maintain proper blood volume and blood pressure. A high sodium diet is …

New strategies for heart failure with preserved ejection fraction: the importance of targeted therapies for heart failure phenotypes

M Senni, WJ Paulus, A Gavazzi, AG Fraser… - European heart …, 2014 - academic.oup.com
The management of heart failure with reduced ejection fraction (HF-REF) has improved
significantly over the last two decades. In contrast, little or no progress has been made in …

Murine models of heart failure with preserved ejection fraction: a “fishing expedition”

M Valero-Muñoz, W Backman, F Sam - Basic to Translational Science, 2017 - jacc.org
Heart failure with preserved ejection fraction (HFpEF) is characterized by signs and
symptoms of heart failure in the presence of a normal left ventricular ejection fraction …

Salt in health and disease—a delicate balance

TA Kotchen, AW Cowley Jr… - New England Journal of …, 2013 - Mass Medical Soc
Salt in Health and Disease — A Delicate Balance | New England Journal of Medicine Skip to
main content The New England Journal of Medicine homepage Advanced Search SEARCH …

Nutrition, obesity, and cachexia in patients with heart failure: a consensus statement from the Heart Failure Society of America Scientific Statements Committee

AR Vest, M Chan, A Deswal, MM Givertz… - Journal of cardiac …, 2019 - Elsevier
Dietary guidance for patients with heart failure (HF) has traditionally focused on sodium and
fluid intake restriction, but dietary quality is frequently poor in patients with HF and may …

Myocardial titin hypophosphorylation importantly contributes to heart failure with preserved ejection fraction in a rat metabolic risk model

N Hamdani, C Franssen, A Lourenço… - Circulation: Heart …, 2013 - Am Heart Assoc
Background—Obesity and diabetes mellitus are important metabolic risk factors and
frequent comorbidities in heart failure with preserved ejection fraction. They contribute to …