Bioactive components, pharmacological effects, and drug development of traditional herbal medicine Rubus chingii Hu (Fu-Pen-Zi)

B He, L Dai, L Jin, Y Liu, X Li, M Luo, Z Wang… - Frontiers in …, 2023 - frontiersin.org
Rubus chingii Hu (Chinese Raspberry), known as Fu-Pen-Zi in Chinese, a woody perennial
plant of the genus Rubus in the Rosaceae family, has specific nutritional and medicinal …

Exploration of novel VEGFR2 tyrosine kinase inhibitors via design and synthesis of new alkylated indolyl-triazole Schiff bases for targeting breast cancer

MS Nafie, ATA Boraei - Bioorganic Chemistry, 2022 - Elsevier
Abstract According to the World Health Organization (WHO) statistics: In 2020, there were
2.3 million women diagnosed with breast cancer and 685,000 deaths globally. Therefore …

Retama monosperma chemical profile, green synthesis of silver nanoparticles, and antimicrobial potential: a study supported by network pharmacology and molecular …

MH Alyami, AM Fakhry, NM El Halfawy, SM Toto… - RSC …, 2023 - pubs.rsc.org
In this study, Retama monosperma extract (RME) was used for the green synthesis of silver
nanoparticles (RME-AgNPs). RME's phenolic profile was identified by liquid …

Discovery of PIM-1 kinase inhibitors based on the 2, 5-disubstituted 1, 3, 4-oxadiazole scaffold against prostate cancer: Design, synthesis, in vitro and in vivo …

AS Castanet, MS Nafie, SA Said, RK Arafa - European Journal of Medicinal …, 2023 - Elsevier
PIM-1 kinases play an established role in prostate cancer development and progression.
This research work tackles the design and synthesis of new PIM-1 kinase targeting 2, 5 …

Comparative Assessment of the Antioxidant and Anticancer Activities of Plicosepalus acacia and Plicosepalus curviflorus: Metabolomic Profiling and In Silico Studies

EE Eltamany, MS Goda, MS Nafie, AM Abu-Elsaoud… - Antioxidants, 2022 - mdpi.com
This study presents a comparison between two mistletoe plants—P. acacia and P.
curviflorus—regarding their total phenolic contents and antioxidant and anticancer activities …

Characterization, antibacterial, antioxidant, antidiabetic, and anti-inflammatory activities of green synthesized silver nanoparticles using Phragmanthera austroarabica …

DM Khodeer, AM Nasr, SA Swidan… - Frontiers in …, 2023 - frontiersin.org
Introduction Diabetes mellitus is a chronic metabolic disorder that exhibited great expansion
all over the world. It is becoming an epidemic disease adding a major burden to the health …

Metabolic Profiling, Chemical Composition, Antioxidant Capacity, and In Vivo Hepato- and Nephroprotective Effects of Sonchus cornutus in Mice Exposed to Cisplatin

SS Elhady, RFA Abdelhameed, ET Mehanna… - Antioxidants, 2022 - mdpi.com
Sonchus cornutus (Asteraceae) is a wild. edible plant that represents a plentiful source of
polyphenolic compounds. For the first time, the metabolic analysis profiling demonstrated …

LC/HRESI-MS/MS screening, phytochemical characterization, and in vitro antioxidant and cytotoxic potential of Jatropha integerrima Jacq. extracts

M Marzouk, SM Khalifa, AH Ahmed, AM Metwaly… - Bioorganic …, 2023 - Elsevier
Avoiding the probable dangerous side effects of synthetic drugs, this study aims the
identification of natural antioxidant and antitumor agents from J. integerrima leaf and floral …

In Vitro and In Vivo Studies of Anti-Lung Cancer Activity of Artemesia judaica L. Crude Extract Combined with LC-MS/MS Metabolic Profiling, Docking Simulation and …

MS Goda, MS Nafie, BM Awad, MS Abdel-Kader… - Antioxidants, 2021 - mdpi.com
Artemisia judaica L.(Family: Asteraceae) exhibited antioxidant, anti-inflammatory, and
antiapoptotic effects. The in vitro cytotoxic activity of A. judaica ethanolic extract was …

Design, synthesis, and docking studies of novel pyrazole-based scaffolds and their evaluation as VEGFR2 inhibitors in the treatment of prostate cancer

DH Soliman, MS Nafie - RSC advances, 2023 - pubs.rsc.org
Since VEGFR-2 plays a crucial role in tumor growth, angiogenesis, and metastasis, it is a
prospective target for cancer treatment. In this work, a series of 3-phenyl-4-(2-substituted …