Machine learning for integrating data in biology and medicine: Principles, practice, and opportunities
New technologies have enabled the investigation of biology and human health at an
unprecedented scale and in multiple dimensions. These dimensions include a myriad of …
unprecedented scale and in multiple dimensions. These dimensions include a myriad of …
The biology and mathematical modelling of glioma invasion: a review
JCL Alfonso, K Talkenberger… - Journal of the …, 2017 - royalsocietypublishing.org
Adult gliomas are aggressive brain tumours associated with low patient survival rates and
limited life expectancy. The most important hallmark of this type of tumour is its invasive …
limited life expectancy. The most important hallmark of this type of tumour is its invasive …
SEACells infers transcriptional and epigenomic cellular states from single-cell genomics data
Metacells are cell groupings derived from single-cell sequencing data that represent highly
granular, distinct cell states. Here we present single-cell aggregation of cell states …
granular, distinct cell states. Here we present single-cell aggregation of cell states …
The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas
INTRODUCTION Therapies targeted against the tumor microenvironment (TME) represent a
promising approach for treating cancer. This appeal arises in part from the decreased …
promising approach for treating cancer. This appeal arises in part from the decreased …
miRNA–target chimeras reveal miRNA 3′-end pairing as a major determinant of Argonaute target specificity
Abstract microRNAs (miRNAs) act as sequence-specific guides for Argonaute (AGO)
proteins, which mediate posttranscriptional silencing of target messenger RNAs. Despite …
proteins, which mediate posttranscriptional silencing of target messenger RNAs. Despite …
ISMARA: automated modeling of genomic signals as a democracy of regulatory motifs
Accurate reconstruction of the regulatory networks that control gene expression is one of the
key current challenges in molecular biology. Although gene expression and chromatin state …
key current challenges in molecular biology. Although gene expression and chromatin state …
miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma
Glioblastoma multiforme (GBM) is a lethal, therapy-resistant brain cancer consisting of
numerous tumor cell subpopulations, including stem-like glioma-initiating cells (GICs), which …
numerous tumor cell subpopulations, including stem-like glioma-initiating cells (GICs), which …
MicroRNA-218 Inhibits Glioma Invasion, Migration, Proliferation, and Cancer Stem-like Cell Self-Renewal by Targeting the Polycomb Group Gene Bmi1
Malignant gliomas are the most common central nervous system tumors and the molecular
mechanism driving their development and recurrence is still largely unknown, limiting the …
mechanism driving their development and recurrence is still largely unknown, limiting the …
Analysis of microRNA-target interactions across diverse cancer types
A Jacobsen, J Silber, G Harinath, JT Huse… - Nature structural & …, 2013 - nature.com
Little is known about the extent to which individual microRNAs (miRNAs) regulate common
processes of tumor biology across diverse cancer types. Using molecular profiles of> 3,000 …
processes of tumor biology across diverse cancer types. Using molecular profiles of> 3,000 …
Dysregulation of miRNA-9 in a subset of schizophrenia patient-derived neural progenitor cells
Converging evidence indicates that microRNAs (miRNAs) may contribute to disease risk for
schizophrenia (SZ). We show that microRNA-9 (miR-9) is abundantly expressed in control …
schizophrenia (SZ). We show that microRNA-9 (miR-9) is abundantly expressed in control …