In response to varying stress signals, the p53 tumor suppressor is able to promote repair,
survival, or elimination of damaged cells–processes that have great relevance to organismal …

For more than 25 years, MDM2 and its homolog MDMX (also known as MDM4) have been
shown to exert oncogenic activity. These two proteins are best understood as negative …

Glioblastoma (GBM) is a prototypical heterogeneous brain tumor refractory to conventional
therapy. A small residual population of cells escapes surgery and chemoradiation, resulting …

Abstract Since Mdm2 (Mouse double minute 2) inhibitors show serious toxicity in clinic
studies, different approaches to achieve therapeutic reactivation of p53-mediated tumor …

Tumor suppressor p53 plays a central role in preventing tumor formation. The levels and
activity of p53 is under tight regulation to ensure its proper function. Murine double minute 2 …

Oral cancer is a sub-category of head and neck cancers that primarily initiates in the oral
cavity. The primary treatment option for oral cancer remains surgery but it is associated with …

The ubiquitin proteasome pathway is critical in restraining the activities of the p53 tumor
suppressor. Numerous E3 and E4 ligases regulate p53 levels. Additionally, deubquitinating …

The p53 pathway is perturbed in the majority of human cancers. Although this most
frequently occurs through the direct mutation or deletion of p53 itself, there are a number of …

Transcription factors regulate hundreds of genes and p53 is no exception. As a stress
responsive protein, p53 transactivates an array of downstream targets which define its role …

The extent to which transcription factors read and respond to specific information content
within short DNA sequences remains an important question that the tumor suppressor p53 is …