The microenvironment is indispensable for functionality of various biomacromolecules,
subcellular compartments, living cells, and organisms. In particular, physical properties …

Simple Summary Although there are various treatments for tumors, chemotherapy is still one
of the most dominant and irreplaceable treatment modalities nowadays. Unfortunately …

Tetrazine-based fluorogenic labels have been extensively applied to the studies of living
systems due to their excellent selectivity, rapid reaction kinetics, and unique fluorogenicity …

Bioelectricity plays an essential role in the structural and functional organization of biological
organisms. In this first article of our three-part series, we summarize the importance of …

The emergence of bioorthogonal reactions has provided numerous opportunities for the
design and fabrication of innovative fluorescence systems, particularly in the analytical field …

Plasma membrane potential is a key driver of the physiology of excitable cells like neurons
and cardiomyocytes. Voltage-sensitive fluorescent indicators offer a powerful complement to …

Among the recent development of click chemistry and bioorthogonal chemistry, fluorogenic
reactions occupy a unique place in that fluorescence is generated from nonfluorescent …

Small-molecule fluorescent probes enabling visualization of the Golgi apparatus in living
cells are essential tools for studying Golgi-associated biological processes and diseases. So …

Cell homeostasis and function rely on well-orchestrated communication between different
organelles. This communication is ensured by signaling pathways and membrane contact …

The endoplasmic reticulum (ER) is a tortuous organelle that spans throughout a cell with a
continuous membrane containing ion channels, pumps, and transporters. It is unclear if …