Merozoite surface proteins in red blood cell invasion, immunity and vaccines against malaria
Malaria accounts for an enormous burden of disease globally, with Plasmodium falciparum
accounting for the majority of malaria, and P. vivax being a second important cause …
accounting for the majority of malaria, and P. vivax being a second important cause …
Parasite recognition and signaling mechanisms in innate immune responses to malaria
DC Gowda, X Wu - Frontiers in immunology, 2018 - frontiersin.org
Malaria caused by the Plasmodium family of parasites, especially P. falciparum and P. vivax,
is a major health problem in many countries in the tropical and subtropical regions of the …
is a major health problem in many countries in the tropical and subtropical regions of the …
Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season
CM Andrade, H Fleckenstein, R Thomson-Luque… - Nature Medicine, 2020 - nature.com
The dry season is a major challenge for Plasmodium falciparum parasites in many malaria
endemic regions, where water availability limits mosquito vectors to only part of the year …
endemic regions, where water availability limits mosquito vectors to only part of the year …
Revealing the Sequence and Resulting Cellular Morphology of Receptor-Ligand Interactions during Plasmodium falciparum Invasion of Erythrocytes
GE Weiss, PR Gilson, T Taechalertpaisarn… - PLoS …, 2015 - journals.plos.org
During blood stage Plasmodium falciparum infection, merozoites invade uninfected
erythrocytes via a complex, multistep process involving a series of distinct receptor-ligand …
erythrocytes via a complex, multistep process involving a series of distinct receptor-ligand …
Human antibodies fix complement to inhibit Plasmodium falciparum invasion of erythrocytes and are associated with protection against malaria
Antibodies play major roles in immunity to malaria; however, a limited understanding of
mechanisms mediating protection is a major barrier to vaccine development. We have …
mechanisms mediating protection is a major barrier to vaccine development. We have …
Targeting Plasmodium PI(4)K to eliminate malaria
CW McNamara, MCS Lee, CS Lim, SH Lim, J Roland… - Nature, 2013 - nature.com
Achieving the goal of malaria elimination will depend on targeting Plasmodium pathways
essential across all life stages. Here we identify a lipid kinase, phosphatidylinositol-4-OH …
essential across all life stages. Here we identify a lipid kinase, phosphatidylinositol-4-OH …
Essential role of the PfRh5/PfRipr/CyRPA complex during Plasmodium falciparum invasion of erythrocytes
JC Volz, A Yap, X Sisquella, JK Thompson, NTY Lim… - Cell host & …, 2016 - cell.com
Plasmodium falciparum parasites in the merozoite stage invade human erythrocytes and
cause malaria. Invasion requires multiple interactions between merozoite ligands and …
cause malaria. Invasion requires multiple interactions between merozoite ligands and …
PTEX is an essential nexus for protein export in malaria parasites
B Elsworth, K Matthews, CQ Nie, M Kalanon… - Nature, 2014 - nature.com
During the blood stages of malaria, several hundred parasite-encoded proteins are exported
beyond the double-membrane barrier that separates the parasite from the host cell …
beyond the double-membrane barrier that separates the parasite from the host cell …
Opsonic phagocytosis of Plasmodium falciparummerozoites: mechanism in human immunity and a correlate of protection against malaria
Background An understanding of the mechanisms mediating protective immunity against
malaria in humans is currently lacking, but critically important to advance the development of …
malaria in humans is currently lacking, but critically important to advance the development of …
[HTML][HTML] Super-resolution dissection of coordinated events during malaria parasite invasion of the human erythrocyte
Erythrocyte invasion by the merozoite is an obligatory stage in Plasmodium parasite
infection and essential to malaria disease progression. Attempts to study this process have …
infection and essential to malaria disease progression. Attempts to study this process have …