Maturation is the last phase of heart development that prepares the organ for strong,
efficient, and persistent pumping throughout the mammal's lifespan. This process is …

Histone methylation can occur at various sites in histone proteins, primarily on lysine and
arginine residues, and it can be governed by multiple positive and negative regulators, even …

Fetal hemoglobin (HbF, α 2 γ 2) level is genetically controlled and modifies severity of adult
hemoglobin (HbA, α 2 β 2) disorders, sickle cell disease, and β-thalassemia. Common …

Single-cell measurement of chromatin states, including histone modifications and non-
histone protein binding, remains challenging. Here, we present a low-cost, efficient …

Background Previous studies showed that the majority of developmental genes are devoid
of DNA methylation at promoters even when they are repressed. Such hypomethylated …

The eukaryotic genome is folded into higher-order conformation accompanied with
constrained dynamics for coordinated genome functions. However, the molecular machinery …

Histone deacetylases (HDACs) regulate gene transcription by catalyzing the removal of
acetyl groups from key lysine residues in nucleosomal histones and via the recruitment of …

Neuroblastoma (NB), an embryonic tumour originating from sympathetic crest cells, is the
most common extracranial solid tumour type in children with poor overall prognosis …

Abstract The EZH2, EED, and SUZ12 genes encode proteins that comprise core
components of the polycomb repressive complex 2 (PRC2), an epigenetic “writer” with …

Efficient cardiac regeneration is closely associated with the ability of cardiac myocytes to
proliferate. Fetal or neonatal mouse hearts containing proliferating cardiac myocytes …