Non-alcoholic fatty liver disease (NAFLD) is a multifactorial disease that encompasses a
spectrum of pathological conditions, ranging from simple steatosis (NAFL), nonalcoholic …

The endoplasmic reticulum (ER) is a cellular organelle important for regulating calcium
homeostasis, lipid metabolism, protein synthesis, and posttranslational modification and …

Background COVID-19 is a multi-system disorder with high variability in clinical outcomes
among patients who are admitted to hospital. Although some cytokines such as interleukin …

Autophagy is a homeostatic process involved in the bulk degradation of cytoplasmic
components, including damaged organelles and proteins. In both genetic and dietary …

Non-alcoholic steatohepatitis (NASH) is characterised by hepatic steatosis and inflammation
and, in some patients, progressive fibrosis leading to cirrhosis. An understanding of the …

The endoplasmic reticulum (ER) is a critical site of protein, lipid, and glucose metabolism,
lipoprotein secretion, and calcium homeostasis. Many of the sensing, metabolizing, and …

Insulin resistance (IR) affects not only the regulation of carbohydrate metabolism but all
aspects of lipid and lipoprotein metabolism. IR is associated with increased secretion of …

As dietary exposure to fructose has increased over the past 40 years, there is growing
concern that high fructose consumption in humans may be in part responsible for the rising …

Obesity is a major problem worldwide that increases risk for a wide range of diseases,
including diabetes and heart disease. As such, it is increasingly important to understand …

The unfolded protein response (UPR) is an evolutionarily conserved cell signaling pathway
that is activated to regulate protein synthesis and restore homeostatic equilibrium when the …