The World Health Organization identifies tuberculosis (TB), caused by Mycobacterium
tuberculosis, as a leading infectious killer. Although conventional treatments for TB exist …

Never has the world been more challenged by respiratory diseases (RDs) than it has
witnessed in the last few decades. This is evident in the plethora of acute and chronic …

Tuberculosis (TB) is one of the oldest diseases known to affect humanity, and is still a major
public health problem. It is caused by the bacillus Mycobacterium tuberculosis (MT), isolated …

Tuberculosis (TB) is a serious infectious disease caused by the bacillus Mycobacterium
tuberculosis (Mtb). The World Health Organization (WHO) estimates that 1.8 million people …

Pyrazinamide analogs 5a–h have been successfully synthesized by the Yamaguchi
esterification method with yields ranging from 6% to 86%. Among pyrazinamides 5a–h …

Background Although diagnosis and treatment services for tuberculosis (TB) are provided
free of charge in most countries, direct non-medical and indirect costs due to absenteeism …

Background: The aim of the study is to identify a novel furan-based chalcone derivative as
potent inhibitor against the H37Rv strain. Materials & methods: The in silico pharmacokinetic …

Abstract Background Line probe assays (LPAs) are PCR-based assays used for the rapid
diagnosis of Mycobacterium tuberculosis (MTB) and drug-resistant tuberculosis (DR-TB). But …

Host metabolism has recently gained more attention for its roles in physiological functions
and pathologic conditions. Of these, metabolic tryptophan disorders generate a pattern of …

Infection by Mycobacterium tuberculosis (Mtb) remains a major global concern and the
available Bacillus Calmette-Guerin (BCG) vaccine is poorly efficacious in adults. Therefore …