Meningeal lymphatics clear erythrocytes that arise from subarachnoid hemorrhage

J Chen, L Wang, H Xu, L Xing, Z Zhuang… - Nature …, 2020 - nature.com
Extravasated erythrocytes in cerebrospinal fluid (CSF) critically contribute to the
pathogenesis of subarachnoid hemorrhage (SAH). Meningeal lymphatics have been …

Blood and lymphatic vasculatures on-chip platforms and their applications for organ-specific in vitro modeling

AR Henderson, H Choi, E Lee - Micromachines, 2020 - mdpi.com
The human circulatory system is divided into two complementary and different systems, the
cardiovascular and the lymphatic system. The cardiovascular system is mainly concerned …

[HTML][HTML] Implications of lymphatic alterations in the pathogenesis and treatment of inflammatory bowel disease

L Zhang, DKW Ocansey, L Liu, CV Olovo… - Biomedicine & …, 2021 - Elsevier
Inflammatory bowel disease (IBD) is characterized by intense immune dysregulation, gut
microbiota imbalance, and intestinal epithelium destruction. Among the factors that …

Lymphangiocrine signals are required for proper intestinal repair after cytotoxic injury

B Palikuqi, J Rispal, EA Reyes, D Vaka, D Boffelli… - Cell Stem Cell, 2022 - cell.com
The intestinal epithelium undergoes continuous renewal and has an exceptional capacity to
regenerate after injury. Maintenance and proliferation of intestinal stem cells (ISCs) are …

Lipopolysaccharides modulate intestinal epithelial permeability and inflammation in a species-specific manner

M Stephens, PY von der Weid - Gut microbes, 2020 - Taylor & Francis
Patients presenting with Inflammatory bowel disease have been shown to exhibit an altered
microbiome in both Crohn's disease and Ulcerative colitis. This shift in the microbial content …

Exosomes derived from human umbilical cord mesenchymal stem cells regulate lymphangiogenesis via the miR-302d-3p/VEGFR3/AKT axis to ameliorate …

L Zhang, J Yuan, DKW Ocansey, B Lu, A Wan… - International …, 2022 - Elsevier
Background Exosomes released from human umbilical cord mesenchymal stem cell
(hucMSC-Ex) have been revealed to hold great potential for the development of new …

[HTML][HTML] IL-17-driven induction of Paneth cell antimicrobial functions protects the host from microbiota dysbiosis and inflammation in the ileum

T Brabec, M Vobořil, D Schierová, E Valter… - Mucosal …, 2023 - Elsevier
Interleukin (IL)-17 protects epithelial barriers by inducing the secretion of antimicrobial
peptides. However, the effect of IL-17 on Paneth cells (PCs), the major producers of …

The role of the lymphatic system in the pathogenesis and treatment of inflammatory bowel disease

D Nikolakis, FAE de Voogd, MJ Pruijt… - International journal of …, 2022 - mdpi.com
Although the number of therapeutic options for the treatment of inflammatory bowel disease
(IBD) has increased in recent years, patients suffer from decreased quality of life due to non …

Polysaccharide from Smilax glabra Roxb Mitigates Intestinal Mucosal Damage by Therapeutically Restoring the Interactions between Gut Microbiota and Innate …

M Abaidullah, S La, M Liu, B Liu, Y Cui, Z Wang, H Sun… - Nutrients, 2023 - mdpi.com
Smilax glabra Roxb (S. glabra) is a conventional Chinese medicine that is mainly used for
the reliability of inflammation. However, bioactive polysaccharides from S. glabra (SGPs) …

Immunomodulatory properties of the lymphatic endothelium in the tumor microenvironment

C Viúdez-Pareja, E Kreft… - Frontiers in …, 2023 - frontiersin.org
The tumor microenvironment (TME) is an intricate complex and dynamic structure composed
of various cell types, including tumor, stromal and immune cells. Within this complex …