[HTML][HTML] Diseases of the nERVous system: retrotransposon activity in neurodegenerative disease
OH Tam, LW Ostrow, M Gale Hammell - Mobile DNA, 2019 - Springer
Abstract Transposable Elements (TEs) are mobile genetic elements whose sequences
constitute nearly half of the human genome. Each TE copy can be present in hundreds to …
constitute nearly half of the human genome. Each TE copy can be present in hundreds to …
[HTML][HTML] The genetics of ductal adenocarcinoma of the pancreas in the year 2020: dramatic progress, but far to go
The publication of the “Pan-Cancer Atlas” by the Pan-Cancer Analysis of Whole Genomes
Consortium, a partnership formed by The Cancer Genome Atlas (TCGA) and International …
Consortium, a partnership formed by The Cancer Genome Atlas (TCGA) and International …
Cell fitness screens reveal a conflict between LINE-1 retrotransposition and DNA replication
D Ardeljan, JP Steranka, C Liu, Z Li… - Nature structural & …, 2020 - nature.com
LINE-1 retrotransposon overexpression is a hallmark of human cancers. We identified a
colorectal cancer wherein a fast-growing tumor subclone downregulated LINE-1, prompting …
colorectal cancer wherein a fast-growing tumor subclone downregulated LINE-1, prompting …
TDP-43 safeguards the embryo genome from L1 retrotransposition
Transposable elements (TEs) are genomic parasites that propagate within the host genome
and introduce mutations. Long interspersed nuclear element-1 (LINE-1 or L1) is the major …
and introduce mutations. Long interspersed nuclear element-1 (LINE-1 or L1) is the major …
[HTML][HTML] Cas9 targeted enrichment of mobile elements using nanopore sequencing
TL McDonald, W Zhou, CP Castro, C Mumm… - Nature …, 2021 - nature.com
Mobile element insertions (MEIs) are repetitive genomic sequences that contribute to
genetic variation and can lead to genetic disorders. Targeted and whole-genome …
genetic variation and can lead to genetic disorders. Targeted and whole-genome …
[HTML][HTML] LINE-1 ORF2p expression is nearly imperceptible in human cancers
Background Long interspersed element-1 (LINE-1, L1) is the major driver of mobile DNA
activity in modern humans. When expressed, LINE-1 loci produce bicistronic transcripts …
activity in modern humans. When expressed, LINE-1 loci produce bicistronic transcripts …
[HTML][HTML] Transposable elements that have recently been mobile in the human genome
Background Transposable elements (TE) comprise nearly half of the human genome and
their insertions have profound effects to human genetic diversification and as well as …
their insertions have profound effects to human genetic diversification and as well as …
[HTML][HTML] Regulation and function of transposable elements in cancer genomes
Over half of human genomic DNA is composed of repetitive sequences generated
throughout evolution by prolific mobile genetic parasites called transposable elements …
throughout evolution by prolific mobile genetic parasites called transposable elements …
[HTML][HTML] Transposable element polymorphisms improve prediction of complex agronomic traits in rice
IT Vourlaki, R Castanera, SE Ramos-Onsins… - Theoretical and Applied …, 2022 - Springer
Key message Transposon insertion polymorphisms can improve prediction of complex
agronomic traits in rice compared to using SNPs only, especially when accessions to be …
agronomic traits in rice compared to using SNPs only, especially when accessions to be …
[HTML][HTML] RIP-seq reveals LINE-1 ORF1p association with p-body enriched mRNAs
Abstract Background Long INterspersed Element-1 (LINE-1) is an autonomous retroelement
able to “copy-and-paste” itself into new loci of the host genome through a process called …
able to “copy-and-paste” itself into new loci of the host genome through a process called …