The role of voltage-gated sodium channels in pain signaling
Acute pain signaling has a key protective role and is highly evolutionarily conserved.
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …
Ion channels in genetic epilepsy: from genes and mechanisms to disease-targeted therapies
Epilepsy is a common and serious neurologic disease with a strong genetic component.
Genetic studies have identified an increasing collection of disease-causing genes. The …
Genetic studies have identified an increasing collection of disease-causing genes. The …
[HTML][HTML] Gut enterochromaffin cells drive visceral pain and anxiety
Gastrointestinal (GI) discomfort is a hallmark of most gut disorders and represents an
important component of chronic visceral pain. For the growing population afflicted by irritable …
important component of chronic visceral pain. For the growing population afflicted by irritable …
Deep sequencing of somatosensory neurons reveals molecular determinants of intrinsic physiological properties
Dorsal root ganglion (DRG) sensory neuron subtypes defined by their in vivo properties
display distinct intrinsic electrical properties. We used bulk RNA sequencing of genetically …
display distinct intrinsic electrical properties. We used bulk RNA sequencing of genetically …
[HTML][HTML] The physiological function of different voltage-gated sodium channels in pain
G Goodwin, SB McMahon - Nature Reviews Neuroscience, 2021 - nature.com
Evidence from human genetic pain disorders shows that voltage-gated sodium channel α-
subtypes Nav1. 7, Nav1. 8 and Nav1. 9 are important in the peripheral signalling of pain …
subtypes Nav1. 7, Nav1. 8 and Nav1. 9 are important in the peripheral signalling of pain …
Structural basis for the modulation of voltage-gated sodium channels by animal toxins
INTRODUCTION Almost all venoms contain toxins that modulate the activity of voltage-gated
sodium (Nav) channels in order to incapacitate prey or predators. The single-chain …
sodium (Nav) channels in order to incapacitate prey or predators. The single-chain …
The diversity of venom: the importance of behavior and venom system morphology in understanding its ecology and evolution
Venoms are one of the most convergent of animal traits known, and encompass a much
greater taxonomic and functional diversity than is commonly appreciated. This knowledge …
greater taxonomic and functional diversity than is commonly appreciated. This knowledge …
Visceral pain
L Grundy, A Erickson, SM Brierley - Annual review of physiology, 2019 - annualreviews.org
Most of us live blissfully unaware of the orchestrated function that our internal organs
conduct. When this peace is interrupted, it is often by routine sensations of hunger and urge …
conduct. When this peace is interrupted, it is often by routine sensations of hunger and urge …
The biology and evolution of spider venoms
Spiders are diverse, predatory arthropods that have inhabited Earth for around 400 million
years. They are well known for their complex venom systems that are used to overpower …
years. They are well known for their complex venom systems that are used to overpower …
Animal toxins—Nature's evolutionary-refined toolkit for basic research and drug discovery
V Herzig, B Cristofori-Armstrong, MR Israel… - Biochemical …, 2020 - Elsevier
Venomous animals have evolved toxins that interfere with specific components of their
victim's core physiological systems, thereby causing biological dysfunction that aids in prey …
victim's core physiological systems, thereby causing biological dysfunction that aids in prey …