CC-1065 and the duocarmycins are the parent members of a potent class of naturally
occurring antitumor antibiotics that exert their biological properties through the sequence …

The duocarmycins (1 and 2) 1 belong to a small family of natural products (Figure 1) that
also include yatakemycin (3) 2 and CC-1065 (4). 3 Their exceptionally potent cytotoxic …

A Perspective of work in our laboratory on the examination of biologically active compounds,
especially natural products, is presented. In the context of individual programs and along …

In spite of the impressive progress in diagnosis, surgery and therapy that occurred since the
Sixties, the overall cancer mortality is still high and the medical need is largely unmet. A …

A series of cobalt (III) complexes of the potent DNA minor groove alkylator (1-(chloromethyl)-
5-hydroxy-1 H-pyrrolo [3, 2-f] quinolin-3 (2 H)-yl)(5, 6, 7-trimethoxy-1 H-indol-2-yl) …

This invention relates to a class of heterocycles and their metal complexes, and is
particularly concerned with the use of these compounds in the preparation of prodrugs or as …

An extensive series of CBI analogues of the duocarmycins and CC-1065 exploring
substituent effects within the first indole DNA binding subunit is detailed. In general …

An unprecedented metal-stabilized phenoxonium cation was prepared by a process
involving dearomatization of a phenoxy complex. The unique η2 CO− metal (iridium) …

The solution-phase, parallel synthesis and evaluation of a library of 132 (+)-1, 2, 9, 9a-
tetrahydrocyclopropa [c] benz [e] indol-4-one (CBI) analogues of CC-1065 and the …

Modified nucleosides in natural RNA molecules are essential for their functions. Non-natural
nucleoside analogues have been introduced into RNA to manipulate its structure and …