Mammalian carboxylesterases are key serine hydrolases that catalyze the hydrolysis of a
wide variety of ester compounds in the corresponding carboxylic acids and alcohols. In …

Remdesivir, an intravenous nucleotide prodrug, has been approved for treating COVID-19 in
hospitalized adults and pediatric patients. Upon administration, remdesivir can be readily …

Carboxylesterases (CEs) are enzymes responsible for the detoxification of insecticides in
insects. In the Cydia pomonella, CEs are involved in synthetic pyrethroid, neonicotinoid …

Increased hydrolysis of cocaine to nontoxic compounds is a promising way to prevent
cocaine-induced toxicity. However, the short half-life of cocaine in the blood and the rapid …

Given the important role of carboxylesterase 2 (CES2) in the metabolism of various esters, it
is of significance to develop a tool to determine endogenous CES2 activity in a rapid and …

This report describes the metabolic glycoengineering (MGE) of intracellular esterase activity
in human colon cancer (LS174T) and Chinese hamster ovary (CHO) cells. In silico analysis …

Introduction: Alisol B 23-acetate (AB23A), a major bioactive constituent in the Chinese herb
Zexie (Rhizoma Alismatis), has been found with multiple pharmacological activities. AB23A …

Pig carboxylesterases (CESs) are recognized as enzymes that metabolize xenobiotics, and
many drugs used in pig breeding that contain ester groups can be hydrolyzed by CESs …

Herein we compare the fluorimetric determination of total and specific carboxylesterase
activity in immortalized human derived living cells and in cell lysates. The cell lines chosen …

Abstract Human carboxylesterase 2 (hCES2) is a glycoprotein involved in the metabolism of
drugs and several environmental xenobiotics, whose crystallization has been proved to be a …