Betulin, a pentacyclic triterpene and a plant pentacyclic triterpene metabolite, can be found
in large quantities in the outer bark of the birches (Betula, Betulaceae). Betulinic acid …

Betulin (B) and Betulinic acid (BA) are natural pentacyclic lupane-structure triterpenoids
which possess a wide range of pharmacological activities. Recent evidence indicates that B …

Irrespective of the morphological features of end-stage cell death (that may be apoptotic,
necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is …

Today cancer treatment is not only a question of eliminating cancer cells by induction of cell
death. New therapeutic strategies also include targeting the tumour microenvironment …

Betulin (lup-20 (29)-ene-3β, 28-diol) is an abundant naturally occurring triterpene and it is
found predominantly in bushes and trees forming the principal extractive (up to 30% of dry …

Abstract 3β‐Hydroxy‐lup‐20 (29)‐en‐28‐oic acid (betulinic acid) is a pentacyclic lupane‐
type triterpene that is widely distributed throughout the plant kingdom. A variety of biological …

Betulinic acid is a triterpene with selective cytotoxicity against melanoma, neuroectodermal
and malignant brain tumor cell lines. In this study the betulinic acid activity was evaluated, in …

Defective cytochrome c release and the resulting loss of caspase-3 activation was recently
shown to be essential for the susceptibility of human melanoma cells to CD95/Fas-induced …

Cancer is a devastating disease and is the second leading cause of death worldwide.
Surgery, chemotherapy (CT), and/or radiation therapy (RT) are the treatment of choice for …

Betulinic acid is a natural product with a range of biological effects, for example potent
antitumor activity. This anticancer property is linked to its ability to induce apoptotic cell …