Vaccine adjuvants: mechanisms and platforms

T Zhao, Y Cai, Y Jiang, X He, Y Wei, Y Yu… - Signal transduction and …, 2023 - nature.com
Adjuvants are indispensable components of vaccines. Despite being widely used in
vaccines, their action mechanisms are not yet clear. With a greater understanding of the …

The use of RNA-based treatments in the field of cancer immunotherapy

M Chehelgerdi, M Chehelgerdi - Molecular Cancer, 2023 - Springer
Over the past several decades, mRNA vaccines have evolved from a theoretical concept to a
clinical reality. These vaccines offer several advantages over traditional vaccine techniques …

Bioinspired and biomimetic delivery platforms for cancer vaccines

J Liu, SS Liew, J Wang, K Pu - Advanced Materials, 2022 - Wiley Online Library
Cancer vaccines aim at eliciting tumor‐specific responses for the immune system to identify
and eradicate malignant tumor cells while sparing the normal tissues. Furthermore, cancer …

The Development of Chiral Nanoparticles to Target NK Cells and CD8+ T Cells for Cancer Immunotherapy

W Wang, J Zhao, C Hao, S Hu, C Chen… - Advanced …, 2022 - Wiley Online Library
The chirality of nanomaterials (nanoparticles, NPs) can influence their interaction with cells
and biological systems. However, how chirality can exert impact on the immune response …

Exosome-loaded degradable polymeric microcapsules for the treatment of vitreoretinal diseases

H Bao, Y Tian, H Wang, T Ye, S Wang, J Zhao… - Nature Biomedical …, 2024 - nature.com
The therapeutic benefits of many cell types involve paracrine mechanisms. Inspired by the
paracrine functions of exosomes and the sustained degradation properties of …

[HTML][HTML] Sustained delivery approaches to improving adaptive immune responses

BS Ou, OM Saouaf, J Baillet, EA Appel - Advanced Drug Delivery Reviews, 2022 - Elsevier
The immune system is one of the most important, complex biological networks regulating
and protecting human health. Its precise modulation can prevent deadly infections and fight …

Polymeric nanoparticle-based nanovaccines for cancer immunotherapy

Y Zhang, J Chen, L Shi, F Ma - Materials Horizons, 2023 - pubs.rsc.org
Therapeutic cancer vaccines, which are designed to amplify tumor-specific T cell responses,
have been envisioned as one of the most powerful tools for effective cancer immunotherapy …

[HTML][HTML] Antibody-based drug delivery systems for cancer therapy: Mechanisms, challenges, and prospects

Z Chen, RK Kankala, Z Yang, W Li, S Xie, H Li… - Theranostics, 2022 - ncbi.nlm.nih.gov
In recent years, antibody-based cancer therapy has emerged as one of the efficient
therapeutic strategies, such as immune checkpoint inhibitors (ICIs), angiogenesis inhibitors …

Hematopoietic stem and progenitor cell membrane-coated vesicles for bone marrow-targeted leukaemia drug delivery

J Li, H Wu, Z Yu, Q Wang, X Zeng, W Qian, S Lu… - Nature …, 2024 - nature.com
Leukemia is a kind of hematological malignancy originating from bone marrow, which
provides essential signals for initiation, progression, and recurrence of leukemia. However …

Nanotechnology-empowered vaccine delivery for enhancing CD8+ T cells-mediated cellular immunity

G Liu, M Zhu, X Zhao, G Nie - Advanced drug delivery reviews, 2021 - Elsevier
After centuries of development, using vaccination to stimulate immunity has become an
effective method for prevention and treatment of a variety of diseases including infective …