Crystallization is one of the most important unit operations used for the separation and
purification of crystalline solid products. Appropriate design and control of the crystallization …

The academic literature on and industrial practice of control of solution crystallization
processes have seen major advances in the past 15 years that have been enabled by …

The last two years have seen groundbreaking advances in natural language processing
(NLP) with the advent of applications like ChatGPT, Codex, and ChatSonic. This revolution …

Population balance modeling is undergoing phenomenal growth in its applications, and this
growth is accompanied by multifarious reviews. This review aims to fortify the model's …

Given the hesitance surrounding the direct implementation of black-box tools due to safety
and operational concerns, fully data-driven deep-neural-network (DNN)-based digital twins …

Crystallization is the main separation and purification process for the manufacturing of drug
substances. Not only does crystallization affect the efficiency of downstream operations such …

NMPC explicitly addresses constraints and nonlinearities during the feedback control of
batch processes. This NMPC algorithm also explicitly takes parameter uncertainty into …

Secondary nucleation can bring the crystallization process into a more easily controlled
state, and it is playing an important role in controlling crystal size distribution, polymorphism …

A systematic approach is developed for the in situ control of the crystal size distribution, and
is applied to the aqueous crystallization of paracetamol (acetaminophen) as a model …

The control of crystal size distribution (CSD) in pharmaceutical crystallization is of primary
importance, as downstream processes such as filtration or drying are greatly affected by the …