[HTML][HTML] Hyperglycemia and oxidative stress: An integral, updated and critical overview of their metabolic interconnections

P González, P Lozano, G Ros, F Solano - International Journal of …, 2023 - mdpi.com
This review focuses on the multiple and reciprocal relationships that exist between oxidative
stress, hyperglycemia and diabetes and related metabolic disorders. Human metabolism …

[HTML][HTML] Vascular dysfunction in preeclampsia

MA Opichka, MW Rappelt, DD Gutterman, JL Grobe… - Cells, 2021 - mdpi.com
Preeclampsia is a life-threatening pregnancy-associated cardiovascular disorder
characterized by hypertension and proteinuria at 20 weeks of gestation. Though its exact …

Oxidative stress-induced endothelial dysfunction in cardiovascular diseases

A Shaito, K Aramouni, R Assaf, A Parenti, A Orekhov… - 2022 - qspace.qu.edu.qa
Cardiovascular disease (CVD) is a major cause of mortality worldwide. A better
understanding of the mechanisms underlying CVD is key for better management or …

[HTML][HTML] Modulation of NRF2/KEAP1 signaling in preeclampsia

G Tossetta, S Fantone, F Piani, C Crescimanno… - Cells, 2023 - mdpi.com
Placentation is a key and tightly regulated process that ensures the normal development of
the placenta and fetal growth. Preeclampsia (PE) is a hypertensive pregnancy-related …

[HTML][HTML] Role of oxidative stress in the dysfunction of the placental endothelial nitric oxide synthase in preeclampsia

P Guerby, O Tasta, A Swiader, F Pont, E Bujold… - Redox biology, 2021 - Elsevier
Preeclampsia (PE) is a multifactorial pregnancy disease, characterized by new-onset
gestational hypertension with (or without) proteinuria or end-organ failure, exclusively …

[HTML][HTML] Inflammation in preeclampsia: genetic biomarkers, mechanisms, and therapeutic strategies

Y Wang, B Li, Y Zhao - Frontiers in immunology, 2022 - frontiersin.org
Objective Preeclampsia is a common and serious complication of pregnancy, posing a
threat to maternal and fetal safety due to the lack of effective biomarkers and treatment …

[HTML][HTML] Gestational diabetes mellitus: the crosslink among inflammation, nitroxidative stress, intestinal microbiota and alternative therapies

ELSS de Mendonça, MBT Fragoso, JM de Oliveira… - Antioxidants, 2022 - mdpi.com
Gestational diabetes mellitus (GDM) is characterized by a set of metabolic complications
arising from adaptive failures to the pregnancy period. Estimates point to a prevalence of 3 …

Expression of severe acute respiratory syndrome coronavirus 2 cell entry genes, angiotensin-converting enzyme 2 and transmembrane protease serine 2, in the …

E Bloise, J Zhang, J Nakpu, H Hamada… - American journal of …, 2021 - Elsevier
Background Although there is some evidence that severe acute respiratory syndrome
coronavirus 2 can invade the human placenta, limited data exist on the gestational age …

[HTML][HTML] Mechanisms of endothelial dysfunction in pre-eclampsia and gestational diabetes mellitus: windows into future cardiometabolic health?

CJ McElwain, E Tuboly, FP McCarthy… - Frontiers in …, 2020 - frontiersin.org
Placental insufficiency and adipose tissue dysregulation are postulated to play key roles in
the pathophysiology of both pre-eclampsia (PE) and gestational diabetes mellitus (GDM). A …

[HTML][HTML] Ferritin light chain deficiency-induced ferroptosis is involved in preeclampsia pathophysiology by disturbing uterine spiral artery remodelling

X Yang, Y Ding, L Sun, M Shi, P Zhang, Z Huang… - Redox biology, 2022 - Elsevier
The proteomic analysis from samples of patients with preeclampsia (PE) displayed a low
level of ferritin light chains (FTL), but we do not know what the significance of reduced FTL in …