P-glycoprotein (PGP) is a pivotal transmembrane transporter governing the cellular flux of
diverse substances shielding mammals from toxics. It can thwart the effectiveness of …

Background Ivermectin is an endectocide against many parasites. Though being a
macrocyclic lactone, its activity against bacteria has been less known, possibly due to the …

Ivermectin and moxidectin are the most widely administered anthelmintic macrocyclic
lactones (MLs) to treat human and animal nematode infections. Their widespread and …

Glioma, the most predominant primary malignant brain tumor, remains uncured due to the
absence of effective treatments. Hence, it is imperative to develop successful therapeutic …

P-glycoproteins (Pgp) have been proposed as contributors to the widespread macrocyclic
lactone (ML) resistance in several nematode species including a major pathogen of foals …

Macrocyclic lactones (MLs) are widely used drugs to treat and prevent parasitic nematode
infections. In many nematode species including a major pathogen of foals, Parascaris …

Abstract Moxidectin (MOX), a broad‑spectrum antiparasitic agent, belongs to the milbemycin
family and is similar to avermectins in terms of its chemical structure. Previous research has …

Macrocyclic lactones (ML) are important anthelmintics used in animals and humans against
parasite nematodes, but their therapeutic success is compromised by the spread of ML …

Background Dirofilaria immitis causes dirofilariosis, a potentially fatal condition in canids.
Dirofilaria infections can be prevented with a macrocyclic lactone (ML) prophylactic regimen …

P-glycoproteins from the ATP-binding cassette transporter family are responsible for drug
evasion by bacterial pathogens and neoplastic cells. More recently, these multidrug …