Targeting adenosine in cancer immunotherapy to enhance T-cell function
S Vigano, D Alatzoglou, M Irving… - Frontiers in …, 2019 - frontiersin.org
T cells play a critical role in cancer control, but a range of potent immunosuppressive
mechanisms can be upregulated in the tumor microenvironment (TME) to abrogate their …
mechanisms can be upregulated in the tumor microenvironment (TME) to abrogate their …
Adenosine as a multi-signalling guardian angel in human diseases: when, where and how does it exert its protective effects?
The importance of adenosine for human health cannot be overstated. Indeed, this ubiquitous
nucleoside is an integral component of ATP, and regulates the function of every tissue and …
nucleoside is an integral component of ATP, and regulates the function of every tissue and …
[HTML][HTML] Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia
The adenosine A1 receptor (A1R) is a promising therapeutic target for non-opioid analgesic
agents to treat neuropathic pain,. However, development of analgesic orthosteric A1R …
agents to treat neuropathic pain,. However, development of analgesic orthosteric A1R …
Cellular function and molecular structure of ecto-nucleotidases
Ecto-nucleotidases play a pivotal role in purinergic signal transmission. They hydrolyze
extracellular nucleotides and thus can control their availability at purinergic P2 receptors …
extracellular nucleotides and thus can control their availability at purinergic P2 receptors …
Medicinal chemistry of adenosine, P2Y and P2X receptors
KA Jacobson, CE Müller - Neuropharmacology, 2016 - Elsevier
Pharmacological tool compounds are now available to define action at the adenosine (ARs),
P2Y and P2X receptors. We present a selection of the most commonly used agents to study …
P2Y and P2X receptors. We present a selection of the most commonly used agents to study …
Historical and current adenosine receptor agonists in preclinical and clinical development
KA Jacobson, DK Tosh, S Jain, ZG Gao - Frontiers in cellular …, 2019 - frontiersin.org
Adenosine receptors (ARs) function in the body's response to conditions of pathology and
stress associated with a functional imbalance, such as in the supply and demand of …
stress associated with a functional imbalance, such as in the supply and demand of …
Enzymes involved in metabolism of extracellular nucleotides and nucleosides: functional implications and measurement of activities
GG Yegutkin - Critical reviews in biochemistry and molecular …, 2014 - Taylor & Francis
Extracellular nucleotides and nucleosides mediate diverse signaling effects in virtually all
organs and tissues. Most models of purinergic signaling depend on functional interactions …
organs and tissues. Most models of purinergic signaling depend on functional interactions …
Pain and poppies: the good, the bad, and the ugly of opioid analgesics
Treating pain is one of the most difficult challenges in medicine and a key facet of disease
management. The isolation of morphine by Friedrich Sertürner in 1804 added an essential …
management. The isolation of morphine by Friedrich Sertürner in 1804 added an essential …
Astrocytes contribute to pain gating in the spinal cord
Various pain therapies have been developed on the basis of the gate control theory of pain,
which postulates that nonpainful sensory inputs mediated by large-diameter afferent fibers …
which postulates that nonpainful sensory inputs mediated by large-diameter afferent fibers …
Adenosine receptor targets for pain
J Sawynok - Neuroscience, 2016 - Elsevier
The main focus for the development of adenosine targets as analgesics to date has been A
1 Rs due to its antinociceptive profile in various preclinical pain models. The usefulness of …
1 Rs due to its antinociceptive profile in various preclinical pain models. The usefulness of …