Retroviral infections are 'mini-symbiotic'events supplying recipient cells with sequences for
viral replication, including the reverse transcriptase (RT) and ribonuclease H (RNase H) …

Protein–RNA and protein–DNA interactions play fundamental roles in many biological
processes. A detailed understanding of these interactions requires knowledge about protein …

Dozens of incurable neurological disorders result from expansion of short repeat sequences
in both coding and non-coding regions of the transcriptome. Short repeat expansions …

Nucleic acid tests (NATs) are essential for biomedical diagnostics. Traditional NATs, often
complex and expensive, have prompted the exploration of toehold-mediated strand …

Abstract G-quadruplexes (G4s) are non-canonical nucleic acid structures formed by guanine
(G)-rich sequences, which are ubiquitously found in the human genome and transcriptome …

We developed a ribonuclease for site-specific targeting and cleavage of single-stranded
RNA. The engineered RNase protein was constructed by incorporating two independent …

Successful downstream molecular analyses of viral ribonucleic acid (RNA) in diagnostic
laboratories, eg, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) or …

A bis‐heteroleptic ruthenium (II) complex, 1 [PF6] 2 of benzothiazole amide substituted 2,
2′‐bipyridine ligand (bmbbipy) has been synthesized for the selective detection of G …

Restriction endonucleases naturally target DNA duplexes. Systematic screening has
identified a small minority of these enzymes that can also cleave RNA/DNA heteroduplexes …

The interphase chromatin structure is extremely complex, precise and dynamic.
Experimental methods can only show the frequency of interaction of the various parts of the …