Immunosenescence is a series of age-related changes that affect the immune system and,
with time, lead to increased vulnerability to infectious diseases. This Review addresses …

Human cytomegalovirus (HCMV) establishes a latent infection that generally remains
asymptomatic in immune-competent hosts for decades but can cause serious illness in …

According to in vitro assays, T cells are thought to kill rapidly and efficiently, but the efficacy
and dynamics of cytotoxic T lymphocyte (CTL)-mediated killing of virus-infected cells in vivo …

A diverse and well-balanced repertoire of T cells is thought to be crucial for the efficacious
defence against infection with new or re-emerging pathogens throughout life. In the last third …

Through genetic recombination, the adaptive immune system generates a diverse T cell
repertoire allowing recognition of a vast spectrum of foreign antigens. Any given CD8+ T cell …

Infection with one of the four serotypes of dengue virus (DENV1–4) can result in a range of
clinical manifestations in humans, from dengue fever to the more serious dengue …

CD8+ T cells are essential effectors in antiviral immunity, recognizing short virus-derived
peptides presented by MHC class I (pMHCI) on the surface of infected cells. However, the …

Antiviral CD8+ T cells respond to only a minute fraction of the potential peptide determinants
encoded by viral genomes. Immunogenic determinants can be ordered into highly …

During persistent murine cytomegalovirus (MCMV) infection, the T cell response is
maintained at extremely high intensity for the life of the host. These cells closely resemble …

CMVs are β herpesviruses that establish lifelong latent infection of their hosts. Acute
infection of C57BL/6 mice with murine CMV elicits a very broad CD8 T cell response …