Sulfated polysaccharides and their lower molecular weight oligosaccharide derivatives from
marine macroalgae have been shown to possess a variety of biological activities. The …

Polysaccharide-based nanoparticles have fascinated attention as a vesicle of different
pharmaceutical agents due to their unique multi-functional groups in addition to their …

Covering: up to August 2001This review covers the structure and function of heparin and
heparan sulfate glycosaminoglycans. Their chemical structures are discussed, including …

Trophoblast research over the past decades has underlined the striking similarities between
the proliferative, migratory and invasive properties of placental cells and those of cancer …

Although the genetic basis of tumorigenesis may vary greatly between different cancer
types, the cellular and molecular steps required for metastasis are similar for all cancer cells …

Heparanase is a β-D-endoglucuronidase that cleaves heparan sulfate (HS), facilitating
degradation of the extracellular matrix (ECM) and the release of HS-bound biomolecules …

J. Clin. Invest. 108: 341–347. DOI: 10.1172/JCI200113662. to a lesser extent, with their
conditioned medium (5). The putative cell surface proteinase that activates the latent …

Heparanase is an endoglycosidase which cleaves heparan sulfate (HS) and hence
participates in degradation and remodeling of the extracellular matrix (ECM). Heparanase is …

The polysaccharide heparan sulphate is ubiquitously expressed as a proteoglycan in
extracellular matrices and on cell surfaces. Heparan sulphate has marked sequence …

Rapidly dividing and invasive cancer cells are strongly dependent on effective lysosomal
function. Accordingly, transformation and cancer progression are characterized by dramatic …