Next generation sequencing of SARS-CoV-2 genomes: challenges, applications and opportunities
Various next generation sequencing (NGS) based strategies have been successfully used in
the recent past for tracing origins and understanding the evolution of infectious agents …
the recent past for tracing origins and understanding the evolution of infectious agents …
Overview: systemic inflammatory response derived from lung injury caused by SARS-CoV-2 infection explains severe outcomes in COVID-19
Most SARS-CoV2 infections will not develop into severe COVID-19. However, in some
patients, lung infection leads to the activation of alveolar macrophages and lung epithelial …
patients, lung infection leads to the activation of alveolar macrophages and lung epithelial …
Test sensitivity is secondary to frequency and turnaround time for COVID-19 screening
The COVID-19 pandemic has created a public health crisis. Because SARS-CoV-2 can
spread from individuals with presymptomatic, symptomatic, and asymptomatic infections, the …
spread from individuals with presymptomatic, symptomatic, and asymptomatic infections, the …
Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection
Understanding the pathophysiology of SARS-CoV-2 infection is critical for therapeutic and
public health strategies. Viral–host interactions can guide discovery of disease regulators …
public health strategies. Viral–host interactions can guide discovery of disease regulators …
Rapid and extraction-free detection of SARS-CoV-2 from saliva by colorimetric reverse-transcription loop-mediated isothermal amplification
MA Lalli, JS Langmade, X Chen, CC Fronick… - Clinical …, 2021 - academic.oup.com
Background Rapid, reliable, and widespread testing is required to curtail the ongoing
COVID-19 pandemic. Current gold-standard nucleic acid tests are hampered by supply …
COVID-19 pandemic. Current gold-standard nucleic acid tests are hampered by supply …
[HTML][HTML] In vivo antiviral host transcriptional response to SARS-CoV-2 by viral load, sex, and age
Despite limited genomic diversity, severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) has shown a wide range of clinical manifestations in different patient populations …
CoV-2) has shown a wide range of clinical manifestations in different patient populations …
[HTML][HTML] Test sensitivity is secondary to frequency and turnaround time for COVID-19 surveillance
The COVID-19 pandemic has created a public health crisis. Because SARS-CoV-2 can
spread from individuals with pre-symptomatic, symptomatic, and asymptomatic infections …
spread from individuals with pre-symptomatic, symptomatic, and asymptomatic infections …
Transcriptional and proteomic insights into the host response in fatal COVID-19 cases
M Wu, Y Chen, H Xia, C Wang… - Proceedings of the …, 2020 - National Acad Sciences
Coronavirus disease 2019 (COVID-19), the global pandemic caused by SARS-CoV-2, has
resulted thus far in greater than 933,000 deaths worldwide; yet disease pathogenesis …
resulted thus far in greater than 933,000 deaths worldwide; yet disease pathogenesis …
A molecular test based on RT-LAMP for rapid, sensitive and inexpensive colorimetric detection of SARS-CoV-2 in clinical samples
Until there is an effective implementation of COVID-19 vaccination program, a robust testing
strategy, along with prevention measures, will continue to be the most viable way to control …
strategy, along with prevention measures, will continue to be the most viable way to control …
Structural basis of RNA cap modification by SARS-CoV-2
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of
COVID-19 illness, has caused millions of infections worldwide. In SARS coronaviruses, the …
COVID-19 illness, has caused millions of infections worldwide. In SARS coronaviruses, the …