The basic principle of adaptive immunity is to strictly discriminate between self and non-self,
and a central challenge to overcome is the enormous variety of pathogens that might be …

T cell activation, proliferation, and differentiation into effector and memory states involve
massive remodeling of T cell size and molecular content and create a massive increase in …

Interferons (IFN) are subdivided into type I IFN (IFN-I, here synonymous with IFN-α/β), type II
(IFN-γ) and type III IFN (IFN-III/IFN-λ) that reprogram nuclear gene expression through …

Treatment of cells with interferon-γ leads to the replacement of the constitutive catalytic
proteasome subunits β1, β2, and β5 by the inducible subunits LMP2 (β1i), MECL-1 (β2i) …

The immunoproteasome is a highly efficient proteolytic machinery derived from the
constitutive proteasome and is abundantly expressed in immune cells. The …

The ubiquitin–proteasome system (UPS) is involved in multiple cellular functions including
the regulation of protein homeostasis, major histocompatibility (MHC) class I antigen …

Multiple sclerosis (MS) is a chronic demyelinating immune mediated disease of the central
nervous system. The immunoproteasome is a distinct class of proteasomes found …

The immunoproteasome, a special class of the proteasome, is mainly expressed in cells of
haematopoietic origin. Additionally, during inflammation, the immunoproteasome is induced …

Background: Immune checkpoint inhibitor (ICI) therapy is often accompanied by immune-
related pathology, with an increasing occurrence of high-risk ICI-related myocarditis …

Numerous cellular processes are controlled by the proteasome, a multicatalytic protease in
the cytosol and nucleus of all eukaryotic cells, through regulated protein degradation. The …