The immunoproteasome and thymoproteasome: functions, evolution and human disease
The basic principle of adaptive immunity is to strictly discriminate between self and non-self,
and a central challenge to overcome is the enormous variety of pathogens that might be …
and a central challenge to overcome is the enormous variety of pathogens that might be …
[HTML][HTML] Protein synthesis, degradation, and energy metabolism in T cell immunity
JM Marchingo, DA Cantrell - Cellular & molecular immunology, 2022 - nature.com
T cell activation, proliferation, and differentiation into effector and memory states involve
massive remodeling of T cell size and molecular content and create a massive increase in …
massive remodeling of T cell size and molecular content and create a massive increase in …
The regulation of inflammation by interferons and their STATs
Interferons (IFN) are subdivided into type I IFN (IFN-I, here synonymous with IFN-α/β), type II
(IFN-γ) and type III IFN (IFN-III/IFN-λ) that reprogram nuclear gene expression through …
(IFN-γ) and type III IFN (IFN-III/IFN-λ) that reprogram nuclear gene expression through …
The immunoproteasome in antigen processing and other immunological functions
M Basler, CJ Kirk, M Groettrup - Current opinion in immunology, 2013 - Elsevier
Treatment of cells with interferon-γ leads to the replacement of the constitutive catalytic
proteasome subunits β1, β2, and β5 by the inducible subunits LMP2 (β1i), MECL-1 (β2i) …
proteasome subunits β1, β2, and β5 by the inducible subunits LMP2 (β1i), MECL-1 (β2i) …
New insights into the function of the immunoproteasome in immune and nonimmune cells
H Kimura, P Caturegli, M Takahashi… - Journal of immunology …, 2015 - Wiley Online Library
The immunoproteasome is a highly efficient proteolytic machinery derived from the
constitutive proteasome and is abundantly expressed in immune cells. The …
constitutive proteasome and is abundantly expressed in immune cells. The …
[HTML][HTML] Role of proteasomes in inflammation
CC Goetzke, F Ebstein, T Kallinich - Journal of clinical medicine, 2021 - mdpi.com
The ubiquitin–proteasome system (UPS) is involved in multiple cellular functions including
the regulation of protein homeostasis, major histocompatibility (MHC) class I antigen …
the regulation of protein homeostasis, major histocompatibility (MHC) class I antigen …
Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis
Multiple sclerosis (MS) is a chronic demyelinating immune mediated disease of the central
nervous system. The immunoproteasome is a distinct class of proteasomes found …
nervous system. The immunoproteasome is a distinct class of proteasomes found …
[PDF][PDF] The immunoproteasome: a novel drug target for autoimmune diseases
The immunoproteasome, a special class of the proteasome, is mainly expressed in cells of
haematopoietic origin. Additionally, during inflammation, the immunoproteasome is induced …
haematopoietic origin. Additionally, during inflammation, the immunoproteasome is induced …
Heart-specific immune responses in an animal model of autoimmune-related myocarditis mitigated by an immunoproteasome inhibitor and genetic ablation
M Bockstahler, A Fischer, CC Goetzke, HL Neumaier… - Circulation, 2020 - Am Heart Assoc
Background: Immune checkpoint inhibitor (ICI) therapy is often accompanied by immune-
related pathology, with an increasing occurrence of high-risk ICI-related myocarditis …
related pathology, with an increasing occurrence of high-risk ICI-related myocarditis …
[HTML][HTML] On the role of the immunoproteasome in protein homeostasis
M Basler, M Groettrup - Cells, 2021 - mdpi.com
Numerous cellular processes are controlled by the proteasome, a multicatalytic protease in
the cytosol and nucleus of all eukaryotic cells, through regulated protein degradation. The …
the cytosol and nucleus of all eukaryotic cells, through regulated protein degradation. The …