The Hippo signaling pathway is gaining recognition as an important player in both organ
size control and tumorigenesis, which are physiological and pathological processes that …

The Hippo pathway is a critical transcriptional signaling pathway that regulates cell growth,
proliferation and organ development. The transcriptional enhanced associate domain …

Mammals express four highly conserved TEAD/TEF transcription factors that bind the same
DNA sequence, but serve different functions during development. TEAD-2/TEF-4 protein …

Specification of cell lineages in mammals begins shortly after fertilization with formation of a
blastocyst consisting of trophectoderm, which contributes exclusively to the placenta, and …

During pre-implantation mouse development, embryos form blastocysts with establishment
of the first two cell lineages: the trophectoderm (TE) which gives rise to the placenta, and the …

TEAD proteins are transcription factors that are crucial for development, but also play a role
in cancers. Several developmentally and pathologically important genes are upregulated by …

The TEAD family of transcription factors is necessary for developmental processes. The
family members contain a TEA domain for the binding with DNA elements and a …

The maternal to zygotic transition is the first major transition that occurs following fertilization,
and entails a dramatic reprogramming of gene expression that is essential for continued …

The first wave of transcription, called zygotic genome activation (ZGA), begins during the 2-
cell stage in mouse preimplantation development and marks a vital transition from the …

The cytoplasmic tyrosine kinase Yes has previously been shown to have an important role in
maintaining mouse and human embryonic stem (ES) self-renewal through an unknown …