Acute kidney injury (AKI), once viewed predominantly as a self-limited and reversible
condition, is now recognized as a growing problem associated with significant risks of …

Hypertension is a frequent condition encountered during kidney disease development and a
leading cause in its progression. Hallmark factors contributing to hypertension constitute a …

Background In a previously reported randomized trial of standard and intensive systolic
blood-pressure control, data on some outcome events had yet to be adjudicated and post …

Background Uncertainty exists about whether lowering systolic blood pressure to less than
120 mm Hg is superior to that of less than 140 mm Hg, particularly in patients with diabetes …

The original KDIGO Clinical Practice Guideline for the Management of Blood Pressure in
Chronic Kidney Disease in the chronic kidney disease (CKD) population not receiving …

Importance There are concerns with translating results from the Systolic Blood Pressure
Intervention Trial (SPRINT) into clinical practice because the standardized protocol used to …

Importance Antihypertensive treatments benefit cerebrovascular health and cognitive
function in patients with hypertension, but it is uncertain whether an intensive blood pressure …

OBJECTIVES To evaluate the effect of intensive systolic blood pressure (SBP) control in
older adults with hypertension, considering cognitive and physical function. DESIGN …

Rationale & Objective The Systolic Blood Pressure Intervention Trial (SPRINT) compared
the effect of intensive versus standard systolic blood pressure targets on cardiovascular …

Hypertension affects the vast majority of patients with CKD and increases the risk of
cardiovascular disease, ESKD, and death. Over the past decade, a number of hypertension …