Long non-coding RNAs: definitions, functions, challenges and recommendations
Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …
Transcription regulation by long non-coding RNAs: mechanisms and disease relevance
J Ferrer, N Dimitrova - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Long non-coding RNAs (lncRNAs) outnumber protein-coding transcripts, but their functions
remain largely unknown. In this Review, we discuss the emerging roles of lncRNAs in the …
remain largely unknown. In this Review, we discuss the emerging roles of lncRNAs in the …
Targeting and engineering long non-coding RNAs for cancer therapy
RNA therapeutics (RNATx) aim to treat diseases, including cancer, by targeting or
employing RNA molecules for therapeutic purposes. Amongst the most promising targets …
employing RNA molecules for therapeutic purposes. Amongst the most promising targets …
Small molecule approaches to targeting RNA
S Kovachka, M Panosetti, B Grimaldi… - Nature Reviews …, 2024 - nature.com
The development of innovative methodologies to identify RNA binders has attracted
enormous attention in chemical biology and drug discovery. Although antibiotics targeting …
enormous attention in chemical biology and drug discovery. Although antibiotics targeting …
Discovery of small molecules that target a tertiary-structured RNA
E Menichelli, BJ Lam, Y Wang… - Proceedings of the …, 2022 - National Acad Sciences
There is growing interest in therapeutic intervention that targets disease-relevant RNAs
using small molecules. While there have been some successes in RNA-targeted small …
using small molecules. While there have been some successes in RNA-targeted small …
Identification of RNA structures and their roles in RNA functions
The development of high-throughput RNA structure profiling methods in the past decade has
greatly facilitated our ability to map and characterize different aspects of RNA structures …
greatly facilitated our ability to map and characterize different aspects of RNA structures …
Contemporary progress and opportunities in RNA-targeted drug discovery
AL Garner - ACS Medicinal Chemistry Letters, 2023 - ACS Publications
The surprising discovery that RNAs are the predominant gene products to emerge from the
human genome catalyzed a renaissance in RNA biology. It is now well-understood that …
human genome catalyzed a renaissance in RNA biology. It is now well-understood that …
Recent trends in RNA informatics: a review of machine learning and deep learning for RNA secondary structure prediction and RNA drug discovery
Computational analysis of RNA sequences constitutes a crucial step in the field of RNA
biology. As in other domains of the life sciences, the incorporation of artificial intelligence …
biology. As in other domains of the life sciences, the incorporation of artificial intelligence …
CircIPO7 promotes nasopharyngeal carcinoma metastasis and cisplatin chemoresistance by facilitating YBX1 nuclear localization
X Hong, Q Li, J Li, K Chen, Q He, Y Zhao, Y Liang… - Clinical Cancer …, 2022 - AACR
Purpose: Cisplatin-based chemotherapy effectively improves the distant-metastasis control
in nasopharyngeal carcinoma (NPC), but approximately 30% of patients develop treatment …
in nasopharyngeal carcinoma (NPC), but approximately 30% of patients develop treatment …
Functional domains of nuclear long noncoding RNAs: Insights into gene regulation and intracellular architecture
Recent functional research on long noncoding RNAs (lncRNAs) has revealed their
significant regulatory roles in gene expression and intracellular architecture. Well …
significant regulatory roles in gene expression and intracellular architecture. Well …