Hypothermia therapy is an old and important method of neuroprotection. Until now, many
neurological diseases such as stroke, traumatic brain injury, intracranial pressure elevation …

This review is based on the previous one published in 2010–Secades JJ. Citicoline:
pharmacological and clinical review, 2010 update. Rev Neurol 2011; 52 (Suppl 2): S1-62 …

Stroke is one of the leading causes of death and disability worldwide. Current treatment
strategies for ischemic stroke primarily focus on reducing the size of ischemic damage and …

Background: Cognitive decline after stroke is more common than stroke recurrence. Stroke
doubles the risk of dementia and is a major contributor to vascular cognitive impairment and …

Cold‐inducible RNA binding protein (CIRP) was discovered after the cells were exposed to
a moderate cold shock because its production was induced. Other cellular stresses such as …

This review is based on the previous one published in 2010–Secades JJ. Citicoline:
pharmacological and clinical review, 2010 update. Rev Neurol 2011; 52 (Suppl 2): S1-62 …

We investigated the effect of CDP-choline on brain plasticity markers expression in the acute
phase of cerebral infarct in an experimental animal model. Male Sprague–Dawley rats were …

Background and Purpose—The neuroprotective potential of citicoline in acute ischemic
stroke has been shown in many experimental studies and, although the exact mechanisms …

Choline alfoscerate (α-GPC) is a common choline compound and acetylcholine precursor in
the brain, which has been shown to be effective in the treatment of Alzheimer's disease and …

Ischemic stroke is one of the leading causes of long-lasting disability and death. Two main
strategies have been proposed for the treatment of ischemic stroke: restoration of blood flow …