The lack of a functional vascular supply has, to a large extent, hampered the whole range of
clinical applications of 'successful'laboratory‐based bone tissue engineering strategies. To …

There have been extensive research efforts to develop new strategies for bone tissue
engineering. These have mainly focused on vascularization during the development and …

During skeletal remodeling, pre-osteoclasts and pre-osteoblasts are targeted to critical sites
of the bone to resorb and reconstruct bone matrix, respectively. Coordination of site-specific …

The survival and functioning of a bone biomaterial requires a rapid and stable
vascularization after implantation. However, the mechanisms involved in the context of the …

To engineer tissues with clinically relevant dimensions, one must overcome the challenge of
rapidly creating functional blood vessels to supply cells with oxygen and nutrients and to …

The endothelial cell (EC) is practically ubiquitous in the human body and forms the inner
cellular lining of the entire cardiovascular system. Following tissue injury, the …

An increasing body of data suggest that mesenchymal stem cells (MSCs) reside in a
perivascular niche. To more closely mimic this in vivo microenvironment and for better …

The reconstruction of bone defects based on cell-seeded constructs requires a functional
microvasculature that meets the metabolic demands of the engineered tissue. Therefore …

In the context of prevascularization strategies for tissue‐engineering purposes, co‐culture
systems consisting of outgrowth endothelial cells (OECs) and primary osteoblasts (pOBs) …

The use of biodegradable beta-tricalcium phosphate (β-TCP) scaffolds holds great promise
for bone tissue engineering. However, the effects of β-TCP on bone and endothelial cells …