The role of vascular smooth muscle cells in the development of aortic aneurysms and dissections

KB Rombouts, TAR van Merrienboer… - European journal of …, 2022 - Wiley Online Library
Background Aortic aneurysms (AA) are pathological dilations of the aorta, associated with
an overall mortality rate up to 90% in case of rupture. In addition to dilation, the aortic layers …

Abdominal aortic aneurysm: roles of inflammatory cells

Z Yuan, Y Lu, J Wei, J Wu, J Yang, Z Cai - Frontiers in immunology, 2021 - frontiersin.org
Abdominal aortic aneurysms (AAAs) are local dilations of infrarenal segment of aortas.
Molecular mechanisms underlying the pathogenesis of AAA remain not fully clear. However …

Vascular smooth muscle cells in aortic aneurysm: from genetics to mechanisms

H Lu, W Du, L Ren, MH Hamblin… - Journal of the …, 2021 - Am Heart Assoc
Aortic aneurysm, including thoracic aortic aneurysm and abdominal aortic aneurysm, is the
second most prevalent aortic disease following atherosclerosis, representing the ninth …

The mechanism and therapy of aortic aneurysms

J Gao, H Cao, G Hu, Y Wu, Y Xu, H Cui, HS Lu… - Signal transduction and …, 2023 - nature.com
Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …

Endothelial shear stress signal transduction and atherogenesis: from mechanisms to therapeutics

L He, CL Zhang, Q Chen, L Wang, Y Huang - Pharmacology & therapeutics, 2022 - Elsevier
Atherosclerotic vascular disease and its complications are among the top causes of mortality
worldwide. In the vascular lumen, atherosclerotic plaques are not randomly distributed …

Exosomal miR-17-5p from adipose-derived mesenchymal stem cells inhibits abdominal aortic aneurysm by suppressing TXNIP-NLRP3 inflammasome

J Hu, Y Jiang, X Wu, Z Wu, J Qin, Z Zhao, B Li… - Stem Cell Research & …, 2022 - Springer
Background Preclinical studies have suggested that adipose-derived mesenchymal stem
cells (ADSCs) transplantation can suppress abdominal aortic inflammation and aneurysm …

Abdominal aortic aneurysm formation with a focus on vascular smooth muscle cells

G Qian, O Adeyanju, A Olajuyin, X Guo - Life, 2022 - mdpi.com
Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease that affects,
mostly, the elder population, with a high mortality rate (> 80%) upon rupture. It features a …

The role of autophagy in cardiovascular pathology

D Gatica, M Chiong, S Lavandero… - Cardiovascular …, 2022 - academic.oup.com
Macroautophagy/autophagy is a conserved catabolic recycling pathway in which
cytoplasmic components are sequestered, degraded, and recycled to survive various stress …

Targeting macrophage TFEB-14-3-3 epsilon Interface by naringenin inhibits abdominal aortic aneurysm

Y Jia, L Zhang, Z Liu, C Mao, Z Ma, W Li, F Yu, Y Wang… - Cell Discovery, 2022 - nature.com
Abdominal aortic aneurysm (AAA) is a lethal cardiovascular disease, and there is no proven
drug treatment for this condition. In this study, by using the Connectivity Map (CMap) …

BAF60c prevents abdominal aortic aneurysm formation through epigenetic control of vascular smooth muscle cell homeostasis

G Zhao, Y Zhao, H Lu, Z Chang, H Liu… - The Journal of …, 2022 - Am Soc Clin Investig
Abdominal aortic aneurysm (AAA) is a life-threatening vascular disease. BAF60c, a unique
subunit of the SWItch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complex, is …