COVID‐19 clinical diagnostics and testing technology

CH Chau, JD Strope, WD Figg - Pharmacotherapy: The Journal …, 2020 - Wiley Online Library
Given the global nature of the coronavirus disease 2019 (COVID‐19) pandemic, the need
for disease detection and expanding testing capacity remains critical priorities. This review …

The estimation of diagnostic accuracy of tests for COVID-19: A scoping review

DB Axell-House, R Lavingia, M Rafferty, E Clark… - Journal of Infection, 2020 - Elsevier
Objectives To assess the methodologies used in the estimation of diagnostic accuracy of
SARS-CoV-2 real-time reverse transcription polymerase chain reaction (rRT-PCR) and other …

[HTML][HTML] False negative rate of COVID-19 PCR testing: a discordant testing analysis

JN Kanji, N Zelyas, C MacDonald, K Pabbaraju… - Virology journal, 2021 - Springer
Background COVID-19 is diagnosed via detection of SARS-CoV-2 RNA using real time
reverse-transcriptase polymerase chain reaction (rtRT-PCR). Performance of many SARS …

[HTML][HTML] A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

R Liu, L He, Y Hu, Z Luo, J Zhang - Chemical Science, 2020 - pubs.rsc.org
Rapid and accurate diagnosis of COVID-19 plays an essential role in the current epidemic
prevention and control. Despite the promise of nucleic acid and antibody tests, there is still a …

[HTML][HTML] Real-life clinical sensitivity of SARS-CoV-2 RT-PCR test in symptomatic patients

E Kortela, V Kirjavainen, MJ Ahava, ST Jokiranta… - PloS one, 2021 - journals.plos.org
Background Understanding the false negative rates of SARS-CoV-2 RT-PCR testing is
pivotal for the management of the COVID-19 pandemic and it has implications for patient …

Routine laboratory blood tests predict SARS-CoV-2 infection using machine learning

HS Yang, Y Hou, LV Vasovic, PAD Steel… - Clinical …, 2020 - academic.oup.com
Background Accurate diagnostic strategies to identify SARS-CoV-2 positive individuals
rapidly for management of patient care and protection of health care personnel are urgently …

The laboratory diagnosis of coronavirus disease 2019—frequently asked questions

FC Fang, SN Naccache… - Clinical Infectious …, 2020 - academic.oup.com
Diagnostic testing has played and will continue to play a major role in the coronavirus
disease 2019 (COVID-19) pandemic. The ability to detect severe acute respiratory syndrome …

Preliminary analysis of association between COVID-19 vaccination and sudden hearing loss using US centers for disease control and prevention vaccine adverse …

EJ Formeister, W Chien, Y Agrawal… - … –Head & Neck …, 2021 - jamanetwork.com
© 2021 American Medical Association. All rights reserved. no association between
vaccination and the rate of SSNHL. 1 Anecdotal reports are rapidly emerging from the …

Suboptimal biological sampling as a probable cause of false-negative COVID-19 diagnostic test results

NN Kinloch, G Ritchie, CJ Brumme… - The Journal of …, 2020 - academic.oup.com
False-negative severe acute respiratory syndrome coronavirus 2 test results can negatively
impact the clinical and public health response to coronavirus disease 2019 (COVID-19). We …

Comparison of the analytical sensitivity of seven commonly used commercial SARS-CoV-2 automated molecular assays

HH Mostafa, J Hardick, E Morehead, JA Miller… - Journal of Clinical …, 2020 - Elsevier
The SARS-CoV-2 pandemic has challenged molecular microbiology laboratories to quickly
implement and validate diagnostic assays and to expand testing capacity in a short …