The cytochrome P450 (CYP) enzymes are a diverse group of heme monooxygenases that,
through the course of their reaction cycle, can contribute to cellular reactive oxygen species …

Some pesticides such as organochlorines are of critical environmental concern because
they are highly persistent due to their stable chemical nature. As a consequence, even after …

In nature, the oxygen reduction reaction (ORR) is catalyzed by cytochrome P450 (CYP)
enzymes containing heme iron centers with an axial thiolate ligand (FeN4‐S), which are …

Metalloporphyrins are widely used throughout the biosphere, and of these heme (iron
protoporphyrin IX, Figure 1) is one of the most abundant and widely used. Heme shuttles …

Abstract The Cytochrome P450 Homepage is a universal resource for nomenclature and
sequence information on cytochrome P450 (CYP) genes. The site has been in continuous …

The cytochrome P450 (CYP) superfamily is the largest enzymatic protein family in plants,
and it also widely exists in mammals, fungi, bacteria, insects and so on. Members of this …

Cytochrome P450 enzymes primarily catalyze mixed-function oxidation reactions, plus some
reductions and rearrangements of oxygenated species, eg prostaglandins. Most of these …

In Candida albicans, the ERG11 gene encodes lanosterol demethylase, the target of the
azole antifungals. Mutations in ERG11 that result in an amino acid substitution alter the …

Recently, increasing interest in natural dietary and therapeutic preparations used as dietary
supplements has been observed. One of them is frankincense. This traditional medicine of …

The cytochromes P450 comprise a family of enzymes that are responsible for around three-
quarters of all drug metabolism reactions that occur in human populations. Many isoforms of …