Hepatic fibrosis is a pathological lesion, characterized by the progressive accumulation of
extracellular matrix (ECM) in the perisinusoidal space and it is a major problem in chronic …

It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer
cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better …

Background & Aims: Viral hepatitis infection, which is a major cause of liver fibrosis, is
associated with activation of innate immunity. However, the role of innate immunity in liver …

BACKGROUND TGFβ is a member of a large family of pleiotropic cytokines that includes
bone morphogenetic proteins (BMPs), activins and other related factors. Mammals have …

Introduction 3. Paracrine soluble factors regulating hepatic stellate cell activation 3.1.
Transforming growth factor-beta 3.2. Tumor necrosis factor-alpha 3.3. Endothelins 3.4 …

Following chronic liver injury of any etiology, there is progressive fibrosis. To date, removing
the causative agent is the only effective therapy to stop or even reverse liver fibrosis …

The name myofibroblast was proposed several years ago for fibroblastic cells located within
granulation tissue and exhibiting an important cytoplasmic microfilamentous apparatus [1 …

T he retractile and remodeling phenomena accompanying and, in pathologic situations,
following the healing of an open wound have attracted the interest of physicians and …

Following acute or chronic liver tissue damage, hepatic stellate cells (HSCs) undergo a
process of activation toward a phenotype characterized by increased proliferation, motility …

Abstract Effects of antioxidants, resveratrol, quercetin, and N-acetylcysteine (NAC) on the
functions of cultured rat hepatic stellate cells and Kupffer cells were studied. These …