Cancer vaccines, which are designed to amplify tumour-specific T cell responses through
active immunization, have long been envisioned as a key tool of effective cancer …

Cancer chemotherapy drugs have long been considered immune suppressive. However,
more recent data indicate that some cytotoxic drugs effectively treat cancer in part by …

Purpose Recurrently mutated genes in myelodysplastic syndrome (MDS) are pathogenic
drivers and powerfully associated with clinical phenotype and prognosis. Whether these …

Hematopoietic stem cell transplantation is a highly specialized and unique medical
procedure. Autologous transplantation allows the administration of high-dose chemotherapy …

Cancer vaccines are promising treatments to prevent relapse after chemotherapy in acute
myeloid leukemia (AML) patients, particularly for those who cannot tolerate intensive …

The process of DNA CpG methylation has been extensively investigated for over 50 years
and revealed associations between changing methylation status of CpG islands and gene …

The immune system is able to detect and eliminate transformed cells. The activating receptor
NKG2D is particularly relevant for cancer immunosurveillance. NKG2D ligand expression …

Therapeutic cancer vaccines aim to generate immunologic targeting of cancer cells through
the induction of effective cellular and antibody-mediated responses specific for antigens …

Allogeneic hematopoietic stem cell transplantation (HSCT) for high-risk acute myeloid
leukemia (AML) represents the only curative option. Progress has been made in the last two …

Relapse is a major cause of treatment failure after allogeneic hematopoietic stem cell
transplantation (alloHSCT). Treatment options for relapse have been inadequate, and the …