Cancer immunotherapy and vaccine development have significantly improved the fight
against cancers. Despite these advancements, challenges remain, particularly in the clinical …

Tumor microenvironment is the general term for all non-cancer components and their
metabolites in tumor tissue. These components include the extracellular matrix, fibroblasts …

Matrigel, a mouse tumor extracellular matrix protein mixture, is an indispensable component
of most organoid tissue culture. However, it has limited the utility of organoids for drug …

The extracellular matrix (ECM) is a vital component of the tumor microenvironment, which
interplays with stromal and tumor cells to stimulate the capacity of cancer cells to proliferate …

Genetic alterations drive tumor onset and progression. However, the cross-talk between
tumor cells and the benign components of the surrounding stroma can also promote the …

Helicobacter pylori is a human microbial pathogen that colonizes the gastric epithelium and
causes type B gastritis with varying degrees of active inflammatory infiltrates. The underlying …

Background The glycosyltransferase CHSY3 is a CHSY family member, yet its importance in
the context of gastric cancer development remains incompletely understood. The present …

PURPOSE Andecaliximab (ADX) is a monoclonal antibody that inhibits matrix
metalloproteinase 9, an extracellular enzyme involved in matrix remodeling, tumor growth …

The development of new advanced constructs resembling structural and functional
properties of human organs and tissues requires a deep knowledge of the morphological …

Objective Gastric cancer is the fifth most common cancer worldwide and the third leading
cause of cancer-related deaths. Insulin-like growth-factor-binding proteins (IGFBPs) were …