Astrocytic processes: from tripartite synapses to the active milieu
A Semyanov, A Verkhratsky - Trends in neurosciences, 2021 - cell.com
We define a new concept of 'active milieu'that unifies all components of nervous tissue
(neuronal and glial compartments, extracellular space, extracellular matrix, and vasculature) …
(neuronal and glial compartments, extracellular space, extracellular matrix, and vasculature) …
Regulation of the hippocampal translatome by Apoer2-ICD release
CR Wasser, GC Werthmann, EM Hall… - Molecular …, 2023 - Springer
Background ApoE4, the most significant genetic risk factor for late-onset Alzheimer's disease
(AD), sequesters a pro-synaptogenic Reelin receptor, Apoer2, in the endosomal …
(AD), sequesters a pro-synaptogenic Reelin receptor, Apoer2, in the endosomal …
Responses in fast-spiking interneuron firing rates to parameter variations associated with degradation of perineuronal nets
The perineuronal nets (PNNs) are sugar coated protein structures that encapsulate certain
neurons in the brain, such as parvalbumin positive (PV) inhibitory neurons. As PNNs are …
neurons in the brain, such as parvalbumin positive (PV) inhibitory neurons. As PNNs are …
Perineuronal Net Microscopy: From Brain Pathology to Artificial Intelligence
M Paveliev, AA Egorchev, F Musin, N Lipachev… - International Journal of …, 2024 - mdpi.com
Perineuronal nets (PNN) are a special highly structured type of extracellular matrix
encapsulating synapses on large populations of CNS neurons. PNN undergo structural …
encapsulating synapses on large populations of CNS neurons. PNN undergo structural …
Increased expression of chondroitin sulfate proteoglycans in dentate gyrus and amygdala causes postinfectious seizures
Alterations in the extracellular matrix are common in patients with epilepsy and animal
models of epilepsy, yet whether they are the cause or consequence of seizures and epilepsy …
models of epilepsy, yet whether they are the cause or consequence of seizures and epilepsy …
Early Chronic Memantine Treatment-Induced Transcriptomic Changes in Wild-Type and Shank2-Mutant Mice
Shank2 is an excitatory postsynaptic scaffolding protein strongly implicated in autism
spectrum disorders (ASDs). Shank2-mutant mice with a homozygous deletion of exons 6 …
spectrum disorders (ASDs). Shank2-mutant mice with a homozygous deletion of exons 6 …
Estimation of cumulative amplitude distributions of miniature postsynaptic currents allows characterising their multimodality, quantal size and variability
A miniature postsynaptic current (mPSC) is a small, rare, and highly variable spontaneous
synaptic event that is generally caused by the spontaneous release of single vesicles. The …
synaptic event that is generally caused by the spontaneous release of single vesicles. The …
Extracellular matrix and synapse formation
L Yang, M Wei, B Xing, C Zhang - Bioscience Reports, 2023 - portlandpress.com
The extracellular matrix (ECM) is a complex molecular network distributed throughout the
extracellular space of different tissues as well as the neuronal system. Previous studies have …
extracellular space of different tissues as well as the neuronal system. Previous studies have …
[HTML][HTML] Infection-induced epilepsy is caused by increased expression of chondroitin sulfate proteoglycans in hippocampus and amygdala
Alterations in the extracellular matrix (ECM) are common in epilepsy, yet whether they are
cause or consequence of disease is unknow. Using Theiler's virus infection model of …
cause or consequence of disease is unknow. Using Theiler's virus infection model of …
[HTML][HTML] Apoer2-ICD-dependent regulation of hippocampal ribosome mRNA loading
C Wasser, GC Werthmann, EM Hall… - Research …, 2023 - ncbi.nlm.nih.gov
Background ApoE4, the most significant genetic risk factor for late-onset Alzheimer's disease
(AD), sequesters a pro-synaptogenic Reelin receptor, Apoer2, in the endosomal …
(AD), sequesters a pro-synaptogenic Reelin receptor, Apoer2, in the endosomal …