Chemosensory signal transduction in Caenorhabditis elegans

DM Ferkey, P Sengupta, ND L'Etoile - Genetics, 2021 - academic.oup.com
Chemosensory neurons translate perception of external chemical cues, including odorants,
tastants, and pheromones, into information that drives attraction or avoidance motor …

C. elegans in high-throughput drug discovery

LP O'Reilly, CJ Luke, DH Perlmutter… - Advanced drug delivery …, 2014 - Elsevier
Caenorhabditis elegans has been proven to be a useful model organism for investigating
molecular and cellular aspects of numerous human diseases. More recently, investigators …

Surgical applications of femtosecond lasers

SH Chung, E Mazur - Journal of biophotonics, 2009 - Wiley Online Library
Femtosecond laser ablation permits non‐invasive surgeries in the bulk of a sample with
submicrometer resolution. We briefly review the history of optical surgery techniques and the …

High-content behavioral analysis of Caenorhabditis elegans in precise spatiotemporal chemical environments

DR Albrecht, CI Bargmann - Nature methods, 2011 - nature.com
To quantitatively understand chemosensory behaviors, it is desirable to present many
animals with repeatable, well-defined chemical stimuli. To that end, we describe a …

Parallel use of two behavioral mechanisms for chemotaxis in Caenorhabditis elegans

Y Iino, K Yoshida - Journal of Neuroscience, 2009 - Soc Neuroscience
Caenorhabditis elegans shows chemotaxis to various odorants and water-soluble
chemoattractants such as NaCl. Previous studies described the pirouette mechanism for …

Odour concentration-dependent olfactory preference change in C. elegans

K Yoshida, T Hirotsu, T Tagawa, S Oda… - Nature …, 2012 - nature.com
The same odorant can induce attractive or repulsive responses depending on its
concentration in various animals including humans. However, little is understood about the …

Running hot and cold: behavioral strategies, neural circuits, and the molecular machinery for thermotaxis in C. elegans and Drosophila

PA Garrity, MB Goodman, AD Samuel… - Genes & …, 2010 - genesdev.cshlp.org
Like other ectotherms, the roundworm Caenorhabditis elegans and the fruit fly Drosophila
melanogaster rely on behavioral strategies to stabilize their body temperature. Both animals …

Functional organization of a neural network for aversive olfactory learning in Caenorhabditis elegans

H Ha, M Hendricks, Y Shen, CV Gabel, C Fang-Yen… - Neuron, 2010 - cell.com
Many animals use their olfactory systems to learn to avoid dangers, but how neural circuits
encode naive and learned olfactory preferences, and switch between those preferences, is …

Neuromodulatory state and sex specify alternative behaviors through antagonistic synaptic pathways in C. elegans

H Jang, K Kim, SJ Neal, E Macosko, D Kim, RA Butcher… - Neuron, 2012 - cell.com
Pheromone responses are highly context dependent. For example, the C. elegans
pheromone ascaroside C9 (ascr# 3) is repulsive to wild-type hermaphrodites, attractive to …

Chemistry and the Worm: Caenorhabditis elegans as a Platform for Integrating Chemical and Biological Research

SE Hulme, GM Whitesides - Angewandte Chemie International …, 2011 - Wiley Online Library
This Review discusses the potential usefulness of the worm Caenorhabditis elegans as a
model organism for chemists interested in studying living systems. C. elegans, a 1 mm long …