Nanoscale extracellular vesicles (EVs), consisting of exomers, exosomes and microvesicles/
ectosomes, have been extensively investigated in the last 20 years, although their biological …

The most widely accepted view of memory in the brain holds that synapses are the storage
sites of memory, and that memories are formed through associative modification of …

Single-cell RNA sequencing (scRNA-seq) enables dissecting cellular heterogeneity in
tissues, resulting in numerous biological discoveries. Various computational methods have …

Early cognitive decline in patients with Alzheimer's (AD) is associated with quantifiable
structural and functional connectivity changes in the brain. AD dysregulation of Aβ and tau …

Extracellular vesicles (EVs), once considered a pathway for cells to remove waste, have now
emerged as an important mechanism for intercellular communication. EVs are particularly …

Amyloid protein cross-seeding is a peculiar phenomenon of cross-spreading among
different diseases. Unlike traditional infectious ones, diseases caused by amyloid protein …

One important facet of glaucoma pathophysiology is axonal damage, which ultimately
disrupts the connection between the retina and its postsynaptic brain targets. The concurrent …

Alzheimer's disease is characterized by two major neuropathological hallmarks—the
extracellular β-amyloid plaques and intracellular neurofibrillary tangles consisting of …

Liquid chromatography-mass spectrometry (LC-MS) is the method of choice for high-
throughput proteomic research. Limited by the peak capacity, the separation performance of …

Brain cells release and take up small extracellular vesicles (sEVs) containing bioactive
nucleic acids. sEV exchange is hypothesized to contribute to stereotyped spread of …