Many approaches to cancer management are often ineffective due to adverse reactions,
drug resistance, or inadequate target specificity of single anti-cancer agents. In contrast, a …

There has been an exponential growth in the performance and output of sequencing
technologies (omics data) with full genome sequencing now producing gigabases of reads …

The molecular classification of glioblastoma (GBM) based on gene expression might better
explain outcome and response to treatment than clinical factors. Whole transcriptome …

Bone metastases (BoM) are a significant cause of morbidity in patients with estrogen
receptor–positive (ER-positive) breast cancer; yet, characterizations of human specimens …

Multi-region sequencing is used to detect intratumor genetic heterogeneity (ITGH) in tumors.
To assess whether genuine ITGH can be distinguished from sequencing artifacts, we …

The use of fresh tissue for molecular studies is preferred but often impossible. Instead,
frozen or formalin-fixed, paraffin-embedded (FFPE) tissues are widely used and constitute …

Many neoplasms remain unclassified after histopathological examination, which requires
further molecular analysis. To this regard, mesenchymal neoplasms are particularly …

High throughput genomic assays empower us to study the entire human genome in short
time with reasonable cost. Formalin fixed‐paraffin‐embedded (FFPE) tissue processing …

Background Formalin-fixed, paraffin-embedded (FFPE) tissues for RNA-seq have
advantages over fresh frozen tissue including abundance and availability, connection to rich …

Identifying a suitable course of immunotherapy treatment for a given patient as well as
monitoring treatment response is heavily reliant on biomarkers detected and quantified in …