Rationale: Interstitial lung abnormalities (ILAs) are associated with the highest genetic risk
locus for idiopathic pulmonary fibrosis (IPF); however, the extent to which there are unique …

The Akirin genes, which encode small, nuclear proteins, were first characterized in 2008 in
Drosophila and rodents. Early studies demonstrated important roles in immune responses …

Embryology of normal web space creation and the genetics of syndactyly in humans and
experimental animals are well described in the literature. In this review, the author offers a 3 …

Introduction: Akirin as a highly conserved transcription factor, exerts a profound influence on
the growth, development, immune response, and reproductive processes in animals. The …

Akirin2 is a key regulator of embryonic development and the innate immunity response.
However, this regulator's role in tumorigenesis especially in cholangiocarcinoma (CCA) …

The fusion of digits or toes, syndactyly, can be part of complex syndromes, including van der
Woude syndrome. A subset of van der Woude cases is caused by dominant-negative …

The axolotl (Ambystoma mexicanum) is a caudate amphibian, which has an extraordinary
ability to restore a wide variety of damaged structures by a process denominated …

Akirin, a conserved metazoan protein, functions in muscle development in flies and mice.
However, this was only tested in the rodent and fly model systems. Akirin was shown to act …

Proper gene regulation is critical for both neuronal development and maintenance as the
brain matures. We previously demonstrated that Akirin2, an essential nuclear protein that …

The Akirin family of transcription cofactors are involved throughout the metazoan in the
regulation of different biological processes such as immunity, interdigital regression, muscle …