Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
We assembled an ancestrally diverse collection of genome-wide association studies
(GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls …
(GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls …
Identification of type 2 diabetes loci in 433,540 East Asian individuals
Meta-analyses of genome-wide association studies (GWAS) have identified more than 240
loci that are associated with type 2 diabetes (T2D),; however, most of these loci have been …
loci that are associated with type 2 diabetes (T2D),; however, most of these loci have been …
Incretin hormones in obesity and related cardiometabolic disorders: the clinical perspective
J Michałowska, E Miller-Kasprzak, P Bogdański - Nutrients, 2021 - mdpi.com
The prevalence of obesity continues to grow rapidly worldwide, posing many public health
challenges of the 21st century. Obese subjects are at major risk for serious diet-related …
challenges of the 21st century. Obese subjects are at major risk for serious diet-related …
New insights into beta-cell GLP-1 receptor and cAMP signaling
A Tomas, B Jones, C Leech - Journal of molecular biology, 2020 - Elsevier
Harnessing the translational potential of the GLP-1/GLP-1R system in pancreatic beta cells
has led to the development of established GLP-1R-based therapies for the long-term …
has led to the development of established GLP-1R-based therapies for the long-term …
Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population
To understand the genetics of type 2 diabetes in people of Japanese ancestry, we
conducted A meta-analysis of four genome-wide association studies (GWAS; 36,614 cases …
conducted A meta-analysis of four genome-wide association studies (GWAS; 36,614 cases …
Glucagon-like peptide-1 receptor blockade impairs islet secretion and glucose metabolism in humans
AA Welch, RA Farahani, AM Egan… - The Journal of …, 2023 - Am Soc Clin Investig
BACKGROUND Proglucagon can be processed to glucagon-like peptide1 (GLP-1) within
the islet, but its contribution to islet function in humans remains unknown. We sought to …
the islet, but its contribution to islet function in humans remains unknown. We sought to …
Evaluation of Evidence for Pathogenicity Demonstrates That BLK, KLF11, and PAX4 Should Not Be Included in Diagnostic Testing for MODY
Maturity-onset diabetes of the young (MODY) is an autosomal dominant form of monogenic
diabetes, reported to be caused by variants in 16 genes. Concern has been raised about …
diabetes, reported to be caused by variants in 16 genes. Concern has been raised about …
Human pluripotent stem cells to model islet defects in diabetes
Diabetes mellitus is characterized by elevated levels of blood glucose and is ultimately
caused by insufficient insulin production from pancreatic beta cells. Different research …
caused by insufficient insulin production from pancreatic beta cells. Different research …
Understanding the place for GLP‐1RA therapy: Translating guidelines for treatment of type 2 diabetes into everyday clinical practice and patient selection
CR Andreasen, A Andersen, FK Knop… - Diabetes, Obesity and …, 2021 - Wiley Online Library
Since the first glucagon‐like peptide 1 (GLP‐1) receptor agonist (GLP‐1RA) was approved
in 2005 (exenatide twice daily) for type 2 diabetes (T2D), the class has developed with …
in 2005 (exenatide twice daily) for type 2 diabetes (T2D), the class has developed with …
Earlier age at type 2 diabetes diagnosis is associated with increased genetic risk of cardiovascular disease
OBJECTIVE We investigated genetic risk of cardiovascular disease (CVD) by age at type 2
diabetes (T2D) diagnosis. RESEARCH DESIGN AND METHODS We compared incident …
diabetes (T2D) diagnosis. RESEARCH DESIGN AND METHODS We compared incident …