Regulation of drug transport proteins—From mechanisms to clinical impact: A white paper on behalf of the international transporter consortium
Membrane transport proteins are involved in the absorption, disposition, efficacy, and/or
toxicity of many drugs. Numerous mechanisms (eg, nuclear receptors, epigenetic gene …
toxicity of many drugs. Numerous mechanisms (eg, nuclear receptors, epigenetic gene …
Pharmacoproteomics of brain barrier transporters and substrate design for the brain targeted drug delivery
KM Huttunen, T Terasaki, A Urtti, AB Montaser… - Pharmaceutical …, 2022 - Springer
One of the major reasons why central nervous system (CNS)-drug development has been
challenging in the past, is the barriers that prevent substances entering from the blood …
challenging in the past, is the barriers that prevent substances entering from the blood …
Hepatic solute carrier transporters and drug therapy: Regulation of expression and impact of genetic variation
Organic cation transporters (OCT), organic anion transporting polypeptides (OATP) and
organic anion transporters (OAT) from the solute carrier (SLC) family play an essential role …
organic anion transporters (OAT) from the solute carrier (SLC) family play an essential role …
A Metabolomic Analysis of Sensitivity and Specificity of 23 Previously Proposed Biomarkers for Renal Transporter‐Mediated Drug‐Drug Interactions
A Gessner, F Müller, P Wenisch… - Clinical …, 2023 - Wiley Online Library
Endogenous biomarkers are discussed as tools for detection of drug‐drug interactions
(DDIs) mediated by renal transport proteins, such as organic cation transporter 2 (OCT2) …
(DDIs) mediated by renal transport proteins, such as organic cation transporter 2 (OCT2) …
Iruplinalkib (WX‑0593), a novel ALK/ROS1 inhibitor, overcomes crizotinib resistance in preclinical models for non-small cell lung cancer
Y Yang, Q Zheng, X Wang, S Zhao, W Huang… - Investigational New …, 2023 - Springer
Despite remarkable initial responses of anaplastic lymphoma kinase (ALK) inhibitors in ALK-
positive non-small cell lung cancer (NSCLC) patients, cancers eventually develop …
positive non-small cell lung cancer (NSCLC) patients, cancers eventually develop …
Endogenous markers of kidney function and renal drug clearance processes of filtration, secretion, and reabsorption
LE Thompson, MS Joy - Current opinion in toxicology, 2022 - Elsevier
The kidneys are responsible for maintaining physiologic homeostasis. The kidneys clear a
variety of drugs and other substances through passive (filtration) and active processes that …
variety of drugs and other substances through passive (filtration) and active processes that …
Transporter-mediated drug-drug interactions: regulatory guidelines, in vitro and in vivo methodologies and translation, special populations, and the blood-brain …
LE Russell, J Yadav, BJ Maldonato… - Drug Metabolism …, 2024 - Taylor & Francis
This review, part of a special issue on drug-drug interactions (DDIs) spearheaded by the
International Society for the Study of Xenobiotics (ISSX) New Investigators, explores the …
International Society for the Study of Xenobiotics (ISSX) New Investigators, explores the …
Organic anion transporting polypeptides (OATPs/SLCOs): Pharmacology, toxicology, structure, and transport mechanisms
B Hagenbuch, B Stieger, KP Locher - Pharmacological Reviews, 2024 - Elsevier
Organic anion transporting polypeptides (OATPs) are membrane proteins that mediate the
uptake of a wide range of substrates across the plasma membrane of various cells and …
uptake of a wide range of substrates across the plasma membrane of various cells and …
Utilising Endogenous Biomarkers in Drug Development to Streamline the Assessment of Drug–Drug Interactions Mediated by Renal Transporters: A Pharmaceutical …
HJ Choi, S Madari, F Huang - Clinical Pharmacokinetics, 2024 - Springer
The renal secretion of many drugs is facilitated by membrane transporters, including organic
cation transporter 2, multidrug and toxin extrusion protein 1/2-K and organic anion …
cation transporter 2, multidrug and toxin extrusion protein 1/2-K and organic anion …